新疆维吾尔族居民hsCRP、IL-6与代谢综合征关系

Associations of metabolic syndrome with high-sensitive C-reactive protein and interleukin-6 among Uygur residents in Xinjiang

目的探讨维吾尔族人群高敏C反应蛋白(hsCRP)、白细胞介素6(IL-6)与代谢综合征(MS)及其组分的关系。方法采用免疫比浊法、ELISA法、放射免疫法检测419名(MS组218例,对照组201人)研究对象的hsCRP、IL-6和空腹胰岛素(FINS),并测量身高、体重、血压、腰围(WC)、臀围(HC)及计算体质指数(BMI)和腰臀比(WHR)。结果 MS组hsCRP、IL-6水平均高于对照组(P<0.01);随着MS组分个数的增多,hsCRP、IL-6水平均升高(P<0.01);hsCRP的Q4组与Q1组相比,MS及其组分[高血压、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、高甘油三酯(TG)]检出率均增加(P<0.01,OR值分别为2.17、2.43、3.16、1.89);IL-6的Q4组与Q1组相比,MS及其组分[高血压、低HDL-C、高TG、高胰岛素抵抗指数HOMA-IR)]检出率均增加(P<0.01,OR值分别为6.27、6.28、10.58、4.16、2.11)。结论 MS患者体内hsCRP、IL-6水平明显升高,hsCRP、IL-6与MS及其组分密切相关,hsCRP、IL-6水平升高是MS发生的重要标志。

Objective To investigate associations of metabolic syndrome （MS）and its components with high-sensi- tive C-reactive protein（hsCRP） and interleukin-6 （IL-6） among Uygur residents in Xinjiang Uygur Autonomous Region. Methods hsCRP, IL-6 and fasting insulin （FINS）of 419 residents were detected by using immune nephelometry, en- zyme-linked immunosorbent assay （ELISA）, and radio immunoassay and height, weight, blood pressure, waist circumfer- ence（ WC ）, and hip circumference（ HC ） of the residents were measured; then the body mass index （ BMI ） and waist-to- hip ratio（ WHR） were calculated. Results The concentrations of hsCRP and IL-6 were significantly higher in the resi- dents with MS than those without MS. The level of hsCRP and IL-6 increased gradually along with the increment of the number of MS components（P 〈 0. 01 ）. Detection rates of MS components, such as high blood pressure, hyperglycemia, and insulin resistance, were significantly higher in the residents with high level （quartile 4 ）of hsCRP and IL-6 when com- pared to those with lower level（ quartile 1 ） （P 〈 0. 01 ）. Conclusion The level of hsCRP and IL-6 are higher in Uygur residents with MS and rise along with the increment of the number of MS components. High concentration of serum hsCRP and IL-6 may be a valuable marker for MS.