恶性肿瘤特异性生长因子(TSGF)在小儿恶性实体瘤中的初步研究

Pilot Study of Tumor Special Grown Factor (TSGF) in Infantile Malignant Massive Tumor

目的探讨恶性肿瘤特异性生长因子(TSGF)在小儿恶性实体瘤诊断及判定预后中的临床意义。方法分别检测正常组(95例)、良性肿瘤组(25例)、恶性肿瘤组(16例)及感染组(23例)治疗前后血清中TSGF的浓度,并作动态观察。结果恶性肿瘤组病儿血清中TSGF浓度与正常组比较有显著性差异(P<0.01),良性肿瘤组与正常组比较无差异。感染组病儿在治疗前血清中TSGF浓度与正常组比较有显著性差异(P<0.01),治疗后2周血清中TSFG浓度与正常组比较已无差异性。并观察到恶性肿瘤完全切除后,TSGF有下降的趋势;而病情恶化者,血清TSGF会升高的现象。以60U/ml为正常参考值,则正常组假阳性率为11.6％(11/95),各种常见的小儿恶性肿瘤阳性率为81.3％(13/16)。良性肿瘤组假阳性率为16.0％(4/25)。结论 TSGF对小儿恶性实体瘤有诊断意义,具有广谱性,而且有很高的特异性和敏感性。初步观察对判定预后有作用。炎症对TSGF有很强的干扰性,使用TSGF作恶性肿瘤诊断时,应排除炎症因素。

Objective To investigate the clinical significance of TSGF in diagnosis and estimation of prognosis forinfan-tile malignant massive tumor. Methods The level of TSGF in serum was measured in 95 cases of normal controls, 25 cases of benign tumor, 23 cases of acute infection and 16 cases of malignant massive tumor. Groups of malignant tumor and infection were analysis dynamically before treatment and after treatment. Results The positive rate of TSGF was 81.3% (13/ 16) in malignant tumor group.It was 11.6% (11/95) in normal controls, 16.0% (4/25) in benign tumor and 65.2% (15/23) in infection group.The level of TSGF in serum of malignant tumor was significantly higher than the normal controls (P< 0.01) .There was no significantly correlated between the benign tumor and the normal group (P> 0.01) .Group of infection was higher than the normal controls before the treatment (P < 0.01) , but after two weeks of the treatment, they were down to normal range (P > 0.01) .When the malignant tumor had received effective treatment, and the TSGF in serum could decreased to a significantly low level, but if the tumor recurrence or condition worsen, then it would be upto a high lever. Conclusions Measurement of TSGF in serum can be used in the diagnosis, estimation of prognosis and treatment -monitoring for infantile malignant massive tumor.And had a highly sensitive 、specific and polygenesis.Acute infection would interfere the diagnosis for the malignant tumor.