抗病毒药物联合黄芩苷治疗重症流感的临床疗效观察

Clinical efficacy of baicalin combined with antivirals in the treatment of severe influenza A H1N1 influenza

目的:探讨抗病毒药物联合黄芩苷治疗重症H1N1流感的临床疗效及作用机制。方法:将收治的63例重症H1N1流感患者按照分层随机分组法分为观察组和对照组,对照组给予常规抗病毒药物治疗,观察组给予抗病毒药物联合黄芩苷治疗,观察2组治疗前后临床症状、实验室指标及细胞免疫功能改善情况。结果:观察组肺部影像学检查及临床症状改善情况均显著优于对照组,2组间差异有显著性(P<0.05);观察组细胞免疫功能下降情况得到显著改善,明显优于对照组,2组差异有显著性(P<0.05);观察组临床疗效及实验室检测指标均显著优于对照组,2组间差异有显著性(P<0.05)。结论:抗病毒药物联合黄芩苷能显著改善重症H1N1流感患者临床症状,在提高患者免疫力同时缩短病程,具有重要的临床应用价值。

OBJECTIVE To explore the clinical efficacy of baicalin combined with antivirals in the treatment of severe influ- enza A H1N1 influenza. METtIODS According to a stratified randomization method, 63 cases of patients with severe influenza A H1NI influenza were divided into the observation group and the control group, the control group was given conventional an- tiviral treatment （oseltamivir）, the observation group was given baicalin and antivirals, the clinical symptoms, laboratory pa- rameters and cellular immune function of the two groups were observed. RESULTS The observation group was significantly better than the control group in the clinical symptoms and the chest radiograph, there was significant difference between two groups（P〈0. 05） ; the observation group was significantly better than the control group in the improvement of cellular immune function, the clinical efficacy and laboratory indicators（P〈0. 05）. CONCLUSION Baicalin combined with antivirals can signif- icantly improve the clinical symptoms and immunity of patients with severe influenza A H1N1 influenza, it has important clini- cal value.