2010-2012年武汉市部分医院喹诺酮类药物应用分析

Analysis on the application of quinolones in some hospitals of Wuhan city during 2010-2012

目的:了解喹诺酮类药物使用情况,为合理用药提供依据。方法:对武汉市32家医院2010-2012年喹诺酮类药物使用数量、消耗金额、DDDs和DDC进行统计分析。结果:3年中喹诺酮类药年销售金额分别为12 565.63,11 135.07,16 131.77万元,注射剂占总年销售额的79.58%,78.78%,53.88%,销售金额前列的药物均为左氧氟沙星、加替沙星、莫西沙星、依诺沙星,其中左氧沙星用药频度最高。结论:喹诺酮类抗菌药物临床应用以第3代药物为主,其总体使用量起伏,但注射剂占年销售额的比重逐年下降,卫生部加强抗菌药物管理起到一定的作用。

OBJECTIVE To investigate the states of application of quinolones and provide the evidence for rational use of medicines. METHODS The amount and cost of quinolones consumed in 24 hospitals of Wuhan from 2010- 2012, frequency of drug use （DDDs） and average daily costs （DDC） were analyzed statistically. RESULTS During the passed three years,the an- nual sales of quinolone were around 125. 656 3, 111. 350 7, 161. 317 7 million respectively, in which the injection occupied 79. 58%, 78. 78%, 53. 88%. Levofloxacin,gatifloxacin,moxifloxacin,and enoxacin were ranked at the top in sales,and levo- floxacin had the highest DDDs. CONCLUSION The third generation of quinolones was the dominant drugs in the clinical us age. Cost fluctuation of quinolones was investigated, while the injection occupied decreased year by year. The affect of strengthening the management of antimicrobial agents by the Ministry of Health played a certain role in this respect.