浓缩铀^(235)U脑内污染对新生大鼠神经行为发育的影响

Effects of Cerebral Exposure to Alpha Radiation by^(235) U on Neurobehavior Development of Neonatal Rats

采用多项指标研究2 3 5U对新生大鼠神经行为的影响 ,新生大鼠 (<2 4h)侧脑室单次注入 2 μl不同浓度的2 35U ,各剂量组的浓度分别为 0 ,1,5 ,10 μg/ 2 μl,观察α辐射体对新生大鼠早期神经行为发育的影响。其结果在各组中 ,张耳、体毛生长、萌牙时间未见明显差异 ;而开眼时间、游泳运动、听觉惊愕、向亲性行为和 4种生理性反射如负趋地性、平面翻正、抓握反射、空中翻正在不同剂量污染组中均有延迟 ,并有剂量反应依赖关系。提示2 3

Effects of cerebral exposure to alpha radiation from radionuclide 235 U on the neurobehavior development of neonatal rats were studied by determination of multiple parameters.Neonatal rats were radiated with one single injection of 2 μl alpha radionuclide of 235 U into the lateral ventricle of the rat brain at the 1 st postnatal day(<24hrs)at a dose of 0,1,5,10 μg of 235 U,respectively.These rats were observed for the early neurobehavior development,Among these groups,there was no significant difference in body hair sprouting,pinna detachment,and incisor eruption,In the radiation group,the retardation was found significantly different from those in the controls,such as the age acquisition in physiological markers as eye opening,sensuous function as auditory startle,movement and coordination function,and activity in swimming.Four physiological reflexes,such as negative geotaxis,surface righting,grasping,reflex suspension,and the tendency behavior were also retarded.For most parameters there was a dose dependent effect.The neonatal rats having cerebral exposure to alpha radiation by 235 U showed delayed neurobehavior development.