摘要
以cis-[Ru(Ⅱ)Cl2(DMSO)4]和杂环醛苯甲酰腙为原料,合成2个[Ru(Ⅱ)Cl2(DMSO)2L1,2]型(L1为4-吡啶甲醛苯甲酰腙,L2为2-呋喃甲醛苯甲酰腙)配合物。通过元素分析、红外光谱、紫外光谱和核磁共振氢谱对配合物结构进行了表征,利用循环伏安法研究了配合物的电化学性质,并用打孔琼脂扩散法检测了配合物的抑菌效果。用MTT法测试了配合物对人肺癌细胞株A549的抑制活性,IC50值为195.79 mg/L。
Two [ Ru （ Ⅱ ） C12 （ DMSO）2L1,2 ] type complexes were synthesized by mixing precursor complex cis-[ RuC12 （DMSO）4 ] and heterocyclic aldehyde benzoyl hydrazone in ethanol（ L~ is pyridine- 4-formaldehyde benzoylhydrazone, L2 is furan-2-carboxaldehyde benzoylydrazone）. The new complexes were characterized by means of elemental analysis, IR spectra, UV-Vis spectra and ~HNMR. The electrochemical behavior of the complexes was studied with the help of cyclic voltammetry. The antibacterial activity of the complexes was detected by agar diffusion method. And the anticancer activity of ther complexes was detected by MTI＂ method. The results indicate that the concentration of IC50 is 195.79 mg/L.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2014年第3期358-361,共4页
Fine Chemicals
基金
陕西省教育厅自然科学专项研究计划(09JK769)~~
关键词
钌配合物
电化学性质
抑菌活性
生物活性
医药与日化原料
ruthenium complex
electrochemical property
antibacterial
biological activity
drug and cosmetic materials
