虎斑游蛇的药理作用研究Ⅱ——急性毒性及镇痛作用

Study on the Pathological effect of Natrix Tigrina (Berthold) —Aute Toxic Experiment and analgesic effect

虎斑游蛇提取液对小鼠化学刺激及电刺激引起的疼痛均有明显的镇痛作用。灌胃给药的小鼠急性毒性试验LD50 未能测出 ,而小鼠最大耐受量为 2 0 0g/kg ,为成人临床常用剂量的 30

Alcoholate extraction of Natrix tigrina (Berthold) has been proved to have distinct analgesic effect on the pains of rats used as the subject,which would be irritated by both the chemical and electric ways.While the comparative water extraction only makes its notable impact on the chemical irritation when it has weak influence on the electric one.Concerning on the acute toxic experiment on the rats,the main index LD 50 is found failed to define.But it is still a fact that the maximum endurance of the rats would be up to 200g/kg,which is generally believed as 300 times as the average dose used for adult in clinical practice.