慢阻肺缓解期患者肺功能与体质量及血清补体的相关分析

A STUDY ON CORRELATION BETWEEN BODY WEIGHT AND LUNG FUNCTION AND SERUM COMPLEMENT COMPONENT IN PATIENTS WITH STABLE COPD

目的：探讨慢性阻塞性肺疾病（COPD）患者第一秒用力呼气容积占用力肺活量百分比（FEV1％）与体质量及血清补体C3、C4、的关系。方法：测定27例健康人及40例COPD缓解期患者的体质量、FEV1％及C3、C4。结果：COPD组体质量及C3较健康组低（P＜0．001），C3无差异。FEV1％与体质量及C4水平下降呈正相关（γ＝0．5179，0．5273），C4下降与体质量呈正相关（γ＝0．4873）。结论：COPD缓解期患者肺功能损伤与营养不良及C4降低有关，C4及体质量变化是反应COPD程度及预后的指标之一。提示营养干预及免疫支持直接影响对COPD的疗效。

Objective:To investigate possible correlation between nutritional status and forced expiratory volume in 1 second expressed as percent predicted (FEV 1%) and serum levels of complement components C 3 and C 4 in patients with chronic obstructive pulmonary disease (COPD).Method:Body weight,FEV 1% and serum levels of C 3 and C 4 in 27 healthy subjects and 40 stable COPD patients were determined and studied the correlation between them.Results:Body weight and C 4 serum level in COPD group were much lower than that health group,while C 3 serum level was no significant.A significant and positive correlation was present between FEV 1% and decrease of body weight and C 4 level(γ=0.517 9, 0.527 3 ,respectively).Morever,there was significant correlation between body weight and C 4 level (γ=0.487 3) in patients with COPD.Conclusion:In patents with stable COPD,pulmonary funciton was associated with the decrease of nutritional depletion (ND) and serum level of complement components C 4,which was an indicator of showing the severe degree of COPD and prognosis.These results suggest that nutritional supplementation and immunological supporting treatment directly influence the curative effect of COPD.