工作时间、遗传因素与肠易激综合征的相关性分析

Correlation Analysis between Working Hours and Genetic Factors in Patients with Irritable Bowel Syndrome

目的探讨工作时间、遗传因素与肠易激综合征(irritable bowel syndrome,IBS)的相关性。方法通过自行设计的依据罗马ⅢIBS诊断标准结合工作时间、遗传因素的调查问卷,选择2010年1月—2013年1月在海军总医院消化内科门诊以腹部症状就诊的IBS患者3242例设为观察组、同期健康体检者1520例设对照组。比较两组工作时间及遗传因素,并对工作时间产生的影响因素进行Logistic分析。结果两组每周工作天数、每日工作时间及近亲患有IBS比率方面的差异均有统计学意义(P<0.01)。周工作天数相对较多、日工作时间相对较长均为IBS的保护因素(P<0.01)。结论保证一定的工作时间对于降低IBS的发病率有一定的意义,近亲患有IBS的人群需警惕IBS的发生。

Objective To investigate the correlation between working hours and genetic factors in patients with irritable bowel syndrome （IBS）. Methods Patients visited doctors for abdominal symptoms in gastroenterology depart- ment and healthy controls taking medical examinations during January 2010 and January 2013 filled in the questionnaires designed on Rome m diagnostic criteria for IBS combined with working hours and genetic factors. A total of 3242 patients with IBS were chosen as observation group, while 1520 healthy controls were chosen as control group. Working hours and genetic factors in the two groups were compared, and the influencing factors of working hours were examined by the logis- tic analysis. Results The differences of the two groups in weekly working days, daily working hours and IBS incidence ratio in close relatives were statistically significant （ P 〈 0. 01 ）. The protective factors of IBS were more working days in a week and longer working hours in a day （P 〈 0. 01 ）. Conclusion The limiting of working time can positively reduce the IBS incidence rate, and people whose close relatives have IBS should be cautious against the IBS.