吸烟、饮酒因素对肠易激综合征发病的影响

Effect of Smoking and Drinking Factors on the Pathogenesy of Irritable Bowel Syndrome

目的探讨吸烟、饮酒因素与肠易激综合征(IBS)的相关性。方法通过自行设计的依据罗马ⅢIBS诊断标准结合吸烟、饮酒情况的调查问卷,选择2010年1月—2013年1月在海军总医院消化内科门诊以腹部症状就诊的IBS 3242例设为观察组、同期健康体检者1520例设为对照组,比较两组吸烟及饮酒情况,并对产生的影响因素进行Logistic分析。结果两组在吸烟比率,吸烟者吸烟年数、吸烟量,饮酒者饮酒年数、饮酒种类方面差异均有统计学意义(P<0.05,P<0.01)。吸烟、吸烟年数长、吸烟量大、饮酒年数长、饮白酒及红酒均为IBS患病的危险因素(P<0.05,P<0.01)。结论戒烟及尽可能减少白酒、红酒的摄入对降低IBS发病率有一定意义。

Objective To investigate the correlation between smoking and drinking factors with irritable bowel syndrome （IBS）. Methods Patients visited doctors for abdominal symptoms in gastroenterology department and healthy controls taking medical examinations during January 2010 and January 2013 filled in the questionnaires designed on Rome III diagnostic criteria for IBS combined with smoking conditions. A total of 3242 patients with IBS were chosen as obser- vation group, while 1520 healthy controls were chosen as control group. Smoking and drinking status in the two groups were compared, and the influencing factors were performed the logistic analysis. Results The differences of the two groups in smoking ratio, duration and amount, and drinking duration and brands were statistically significant （P 〈 0. 05, P 〈 0.01 ）. Risk factors were smoking, long smoking history, large volume smoking, long drinking history, drinking white or red wine （P 〈 0.05, P 〈 0.01 ）. Conclusion It is of some significance to quit smoking and drinking as less as possible in reducing the IBS incidence rate.