前列地尔注射液辅助治疗老年冠心病稳定型心绞痛65例

Alprostadil Fat Emulsiom Injection in Treatment of 65 Elderly Patients with Stable Angina of Coronary Heart Disease

目的观察前列地尔注射液辅助治疗老年冠心病稳定型心绞痛的临床效果及血液流变学指标的改变。方法将北京急救中心急诊内科2010年3月—2012年3月收治的老年冠心病稳定型心绞痛128例随机分为观察组65例和对照组63例。对照组予常规治疗;观察组在常规治疗基础上应用前列地尔注射液10μg静脉滴注入壶,1/d。两组均以7 d为1个疗程,共治疗3个疗程。观察两组心绞痛总有效率、心电图总有效率、血液流变学指标改变情况和不良反应。结果治疗3个疗程后,观察组心绞痛、心电图总有效率均高于对照组(P<0.05),血液流变学指标的改善程度也明显优于对照组(P<0.05),且两组均无严重不良反应发生。结论前列地尔注射液辅助治疗老年冠心病稳定型心绞痛安全、有效。

Objective To observe the clinical effectiveness and changes of hemorheology indexes of Alprostadil Fat Emulsiom Injection in treatment of elderly patients with stable angina of coronary heart disease. Methods A total of 128 elderly patients with stable angina of coronary heart disease during March 2010 and March 2012 were randomly divid- ed into treatment group （ n = 65 ） and control group （ n = 63 ）. Control group was treated with conventional treatment ; ob- servation group received 10 μg iv gtt of Alprostadil Fat Emulsiom Injection （1/d） based on conventional treatment. One course of treatment was 7 d, and the two groups were treated for 3 courses. Changes of angina pectoris, the total effective rate of electrocardiogram and hemorheology indexes, and adverse reactions in the two groups were observed. Results After a 3-course treatment, the values of angina pectoris and the total effective rate of electrocardiogram in treatment group were significantly higher than those of control group （P 〈 0.05） ; hemorheology improvement in treatment group was su- perior to that of control group （P 〈 0. 05 ） , and there was no adverse reaction in the two groups. Conclusion Alprostadil Fat Emulsiom Injection in treatment of elderly patients with stable angina of coronary heart disease is safe and effective.