放疗对鼻咽癌患者嗅觉的影响

Observation on the changes in nasopharyngeal carcinoma patients′ olfactory before and after radiotherapy

目的 :探讨放疗对鼻咽癌 (NPC)患者嗅觉的影响。方法 :对 10 0例 NPC患者于放疗前、后 3和 6个月 ,1、2、3年 ,分别进行嗅觉检测 ,比较其变化。结果 :与放疗前比较 ,放疗后 3个月患者嗅觉锐度明显减退 ;0 .5～1年 ,嗅觉有所改善 ,但未能达到放疗前水平 ,且感觉阈与识别阈出现分离 ;此后 ,再次出现嗅觉锐度减退现象。结论 :放疗可影响 NPC患者嗅觉 ,放疗后患者嗅觉呈波浪式、永久性减退。

Objective:Detecting nasopharyngeal carcinoma(NPC) patients′olfactory before and after radiotherapy for investigating the infection of radiotherapy on these patients′olfactory.Method:100 NPC patients′olfactory were detected before the start of radiotherapy and after the termination of therapy in 3,6,12,24 and 36 months.Result:Patients′smell acuity decreased sharply 3 months after therapy,but varying degrees of recovery were noted in 6 and 12 months. However their smell acuity became worse in the following time.Conclusion:NPC patients′smell acuity can be profoundly affected by radiotherapy.And after radiotherapy, their smell acuity will decrease wave likely and cannot fully recover.