摘要
目的制备糠酸莫米松鼻用凝胶,并评价其治疗过敏性鼻炎的效果。方法以2%AvicelRC-591为基质,反溶剂共沉淀法制备糠酸莫米松鼻用凝胶;以10%TDI橄榄油溶液滴鼻建立变应性鼻炎豚鼠模型,经鼻腔给予糠酸莫米松鼻用凝胶治疗,并以糠酸莫米松鼻用喷剂为对照,考察两种剂型药物治疗前后豚鼠的鼻炎症状评分、嗜酸性细胞分泌数量以及鼻黏膜组胺含量变化。结果糠酸莫米松鼻用凝胶能有效抑制豚鼠的鼻炎症状,减少嗜酸性细胞分泌数量以及鼻黏膜组胺含量,效果优于糠酸莫米松鼻用喷剂(P<0.05)。结论糠酸莫米松鼻用凝胶对过敏性鼻炎具有显著效果。
Objective To prepare mometasone furoate nasal gel, and to evaluate its curative effect on allergic rhinitis. Methods 2% Avicel RC-591 was used as the groundmass to prepare mometasone furoate nasal gel by anti-solvent co-precipitation method. Guinea pig model of allergic rhinitis was established through the intranasal administration with 10% TDI olive oil and then treated with mometasone furoate nasal gel. The other guinea pigs treated with mometasone furoate nasal spray were chosen as the control. Investigation was made in the effects of the two medications on the symptom scores of rhinitis, acidophilic cell quantity, and the changes of histamine in nasal mucosa. Results The mometasone furoate nasal gel could effectively inhibit the symptom of rhinitis in the guinea pigs and decrease the acidophilic cell secretion quantity and the content of histamine in nasal mucosa. Its efficiency was superior to that of the mometasone furoate nasal spray ( P 〈 0.05 ). Conclusion Mometasone furoate nasal gel has significant effect on allergic rhinitis.
出处
《西南国防医药》
CAS
2014年第2期149-151,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
变应性鼻炎
莫米松
凝胶
疗效
allergic rhinitis
mometasone furoate
gel
curative effect