帕瑞昔布超前镇痛时对血糖、C-反应蛋白及白细胞介素-6的影响

Parecoxib preemptive analgesia effect and influence on BG,CRP and IL-6

目的探讨帕瑞昔布用于脊柱手术患者超前镇痛效果观察及对相关炎症因子的影响。方法选取80例择期行脊柱手术患者,随机分为观察组与对照组各40例,观察组在麻醉诱导时给予帕瑞昔布40 mg静脉滴注,对照组术后静脉滴注帕瑞昔布40 mg,术后常规给予芬太尼行自控静脉镇痛(PCIA),比较麻醉前(T0)、术毕时(T1)、术后6 h(T2)、术后12 h(T3)时患者血糖(BG)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)浓度及术后不同时点疼痛程度(VAS)评分。结果观察组患者手术时间(136.88±52.48)min,对照组为(130.13±67.41)min,2组比较差异无统计学意义(P>0.05);术后4 h、12 h、24 h时观察组VAS评分明显低于对照组(P<0.05)。结论帕瑞昔布用于脊柱手术患者超前镇痛较术后镇痛能明显减轻术后疼痛程度,利于抑制手术患者应激反应。

Objective To investigate analgesia effect of parecoxib preemptive analgesia and its influence on related inflammatory factors. Methods 80 patients undergoing elective spine surgery patients were randomly divided into observation group and control group, with 40 cases in each group, observation group during anesthesia induction to Pareeoxib 40 mg intravenous drip, and the control group ＇after intravenous drip Parecoxib 40 mg, regular line given fentanyl self-control intravenous analgesia （PCIA） , compare the anesthesia（ TO ） and finish before（ T1 ） ,6 h after surgery （T2） , 12 h after sur- gery （ T3 ） in patients＇ blood glucose （ BG）, C-reactive protein （ CRP）, interleukin-6 （ IL-6 ） concentrations at different time after operation the pain（VAS） score. Results Operation time was （ 136.88 ± 52.48） min,observation group patients in the control group was （ 130.13 ± 67.41 ） rain, there was no statistically significant difference （ P 〉 0.05 ） ; postoperative 4 h, 12 h,24 h VAS score in observation group were obviously lower than those of control group （P 〈 0.05 ）. Conclusion Parecoxib used for spinal surgery patients analgesia can significantly relieve postoperative pain degree, it was conducive to inhibit the surgical stress response.