外周血造血干细胞移植在小儿恶性实体瘤中的应用

Peripheral blood stem cell transplantation to treat solid tumors in children

目的 介绍外周血造血干细胞移植在小儿恶性实体瘤治疗中的应用。方法 小儿恶性实体瘤 7例 ,男 5例 ,女 2例 ,年龄 2～ 8岁。神经母细胞瘤 5例 ,畸胎瘤 1例 ,横纹肌肉瘤 1例。在临床完全缓解或部分缓解后进行造血干细胞移植。其步骤包括外周血造血干细胞的动员和采集 ,数量及活性测定 ,保存和回输 ,预处理以及免疫辅助剂的应用。结果 7例患儿成功地完成了动员、采集、预处理和免疫重建 ,渡过了骨髓抑制期 ,最长无瘤生存期限 2 .5年。结论 外周血造血干细胞移植在小儿实体瘤治疗中具有广阔的前景 ,可以最大程度杀灭肿瘤 ,减少疗程 。

Objective To introduce peripheral blood stem cell transplantation to treat pediatric solid tumors.Methods Seven cases (male 5, female 2) aged from 2 to 8 years of late stage malignant tumors were received peripheral blood stem cell transplantation included irritation, harvest, preconditioning and resuscitation after clinical CR(complete response) or PR (partial response). There were neuroblastoma in 5, teratoma 1 and rhabdomyosarcoma 1.Results All cases passed through bone marrow inhibitory stage uneventfully . The longest tumor-free survival period was 2.5 years.Conclusions Peripheral blood stem cell transplantation has broad perspective in the treatment of children's solid tumors. It can reduce the therapy courses, save cost and improve the quality of life.