摘要
目的用被动吸烟法建立宫内被动吸烟胎鼠及宫内至断乳前持续被动吸烟幼鼠动物模型 ,比较不同浓度香烟暴露对胎鼠及幼鼠血清IGF -Ⅰ的影响。 方法SD雌鼠于交配后第 2d ,入低、中、高三种香烟浓度的被动吸烟箱中 ,每日 5h ,孕 2 1d剖宫取胎 ,收集胎鼠血清 ;或待孕鼠自然分娩 ,幼鼠置于与宫内相同香烟浓度的被动吸烟箱中 ,每日 5h ,至 2 1d断乳 ,取幼鼠血清。 结果不同浓度香烟暴露对胎鼠血清IGF -Ⅰ的影响无显著差异 ,随香烟浓度增高幼鼠血清IGF -Ⅰ呈下降趋势 ,高浓度组与对照组间差异显著。 结论宫内至断乳前持续被动吸烟降低幼鼠血清IGF -Ⅰ水平 ,随香烟浓度增高 ,差异显著。
Objective To evaluate whether environmental tobacco smoke exposure in utero or/and postnatally affects serum IGF- Ⅰ of rats. Methods Pregnant SD rats were exposed to air or to passive smoke for 5h/d, from day 2 to day 21 of pregnancy,then the fetal serum were collected. Or from day 2 of pregnancy until delivery,then their pups were exposed to the same environment till weaning.After completion of the exposures,the pups' serua were collected. Results Utero passive smoke had no effect on fetus's serum IGF- Ⅰ Conclusion Utero till postnatum passive smoke reduced serum IGF-I of pups,in particular decreased significantly in the highest concentration group.
出处
《上海第二医科大学学报》
CSCD
2001年第1期33-34,共2页
Acta Universitatis Medicinalis Secondae Shanghai
