解毒化瘀颗粒治疗重度慢性乙型病毒性肝炎的临床研究

Clinical Observation of Jie-du Hua-yu Particle on Chronic Sever Hepatitis B

目的:观察解毒化瘀颗粒治疗重度慢性乙型病毒性肝炎的临床疗效。方法:将80例重度慢性乙型病毒性肝炎患者随机分为治疗组和对照组各40例。对照组予西医基础对症治疗,治疗组在对照组的基础上加用解毒化瘀颗粒,疗程均为4周。观察比较两组患者治疗前后肝功能(TBIL、ALB、ALT、AST),凝血功能(PTA)及临床症状改善情况。结果:两组患者TBIL、ALB、ALT、AST、PTA及临床症状均有改善,治疗组的TBIL、ALB、ALT、AST、PTA及临床症状的改善程度优于对照组(P<0.05)。结论:解毒化瘀颗粒治疗重度慢性乙型病毒性肝炎有较好的临床疗效。

Objective： To observe the clinical curative effect of jie-du hua-yu particle on chronic sever hepatitis B pa- tients. Methods： The 80 cases of patients with chronic sever hepatitis B patients were randomly assigned either to treatment and control groups, 40 cases in each. Patients received western medicine symptomatic treatment in control group, and jie-du hua-yu particle as well as western medicine symptomatic treatment in treatment group; the treatment course was 4 weeks. The change of liver function （TBIL, ALB, ALT and AST）, coagulation （PTA） and the improvement of clinical symptoms were ob- served and compared in two groups, before and after treatment. Results： The TBIL, ALB, ALT, AST and clinical symptoms improved both in two groups, and the improvement of TBIL, ALB, ALT, AST and clinical symptoms in treatment group was superior to the control group （P〈0.05）. Conclusion： Jie-du hua-yu particle can provide better clinical effect for chronic sever hepatitis B.