国产碳酸利多卡因硬膜外阻滞在上腹部手术中的应用

Applied Research on Using Domestic Produced Carbonate Lidocaine for Epidural Anesthesia in Upper Abdominal Operation

目的评估碳酸利多卡因用于上腹部手术硬膜外阻滞麻醉安全性。 方法择胃、胆囊手术患者 6 0例 ,随机硬膜外注入 1.73%碳酸利多卡因 (碳利组 ,n =30 )或 2 %盐酸利多卡因 (盐利组 ,n =30 )。 结果碳利组麻醉起效时间和作用完全时间早于盐利组 (P <0 .0 1) ,碳利组作用持续时间略短于盐利组 (P >0 .0 5 )。碳利组收缩压降低早于盐利组 (P <0 .0 5 )。 结论碳酸利多卡因用于上腹部硬膜外阻滞麻醉是安全的 ,必须重视注药后早期血压降低。

Objective To evaluate the security of using carbonate lidocaine for epidural anesthesia on upper abdominal operation. Methods 60 patients with gastrectomy or cholecystectomy were injected randomly with 1.73% carbonate lidocaine (CL:n=30) or 2% hydrochloric lidocaine (HL:n=30). Results Group CL onset time and effective entire time of anesthetic is earlier than group HL (P< 0.01 ). Duration of group CL is shorter than that of group HL (P>0.05). Decrease of systolic blood pressure for group CL is earlier than that of group HL (P<0.05). Conclusion Carbonate lidocaine is safe for epidural infusion on upper abdominal operation, Meanwhile, doctors must pay great attention to early decrease of blood pressure.