长时程亚低温治疗重型颅脑损伤疗效观察

Efficacy of long-term mild hypothermia on patient with severe traumatic brain injury

目的 观察长时程亚低温对重度颅脑损伤的临床疗效.方法 2010-05-2012-07我院收治的152例重型颅脑损伤患者,分为长时程亚低温治疗组（观察组）和短时程亚低温治疗组（对照组）,观察组疗程7～14 d,对照组疗程48 h,将2组临床疗效和不良反应进行对比.结果 观察组恢复良好率64.7%,病死率17.6%;对照组恢复良好率38.1%,病死率35.7%;观察组恢复良好率显著高于对照组（P〈0.05）,病死率明显低于对照组（P〈0.05）.观察组总体并发症发生率64.7%,对照组总体并发症发生率71.4%,两者相比差异无统计学意义（P〉0.05）.结论 长时程亚低温治疗能显著降低重型颅脑损伤患者的病死率,改善颅脑损伤患者预后,且并发症少.

Objective To observe the clinical efficacy of long-term mild hypothermia on patient with severe traumatic brain injury. Methods Totally 152 cases with severe traumatic brain injury admitted to our hospital from May 2010 to July 2012 were randomly assigned to long-term mild hypothermia group and short-term mild hypothermia group. Observation group were treated for 7~14 d and control group were treated for 48 hours. The clinical efficacy and adverse reactions were analyzed. Results The rate of good recovery in observation group（64.7~~）was significantly higher than that of control group（38.1%, P〈0.05）. The mortality rate in observation group （17.6%）was significantly lower than that of control group（35.7 %, P〈0.05）. There was no significant difference between observation group （64.7%） and control （71.4%, P〉0.05）. Conclusion Longterm mild hypothermia can significantly reduce mortality in patients with severe traumatic brain jury, and improve prognosis with no more complications.