吉兰-巴雷综合征患者医院感染危险因素分析及防控策略

Analysis on risk factors of nosocomial infection in patients with Guillain-Barre syndrome and preventive interventions

目的探讨吉兰-巴雷综合征患者医院感染的相关因素。方法回顾性分析2008-01-2012-12吉兰-巴雷患者112例,52例发生医院感染的吉兰-巴雷综合征患者作为病例组,随机按照1∶1比例选择同期未发生医院感染的该类患者作为对照组。并将2组可能影响医院感染的因素资料进行单因素及多因素分析。结果单因素分析结果显示,住院时间、侵入性操作、瘫痪卧床、急性期使用激素冲击治疗情况等因素在病例组和对照组的分布差异有统计学意义(P<0.05);多因素分析提示住院时间<15d、进行侵入性操作、瘫痪卧床,急性期使用激素冲击治疗均可能成为吉兰-巴雷综合征患者发生医院感染的危险因素。结论应依据患者不同的危险因素,制定有针对性的措施预防医院感染的发生。

Objective To investigate the risk factors of nosocomial infection （NI） in patients with Guillain-Barre syn- drome. Methods 112 patients with Guillain-Barre syndrome were selected in this study from January 2008 to December 2012. A total of 52 patients with NI were assigned to case group. The control group （patient with Guillain-Barre syndrome and with- out NI in the same period） was randomly selected by 1 ~ 1 ratio. Single factor analysis and the logistic regression model were used to estimate the odds ratio （OR） and its 95~ confidence interval （95~ CI）. Results There were significant difference be- tween the two groups in the length of hospital stay, invasive operation, paralysis in bed, the use of corticosteroid therapy in a cute stage （P〈0.05）. The possible risk {actors of NI might include： the length of hospital stay less than 15 days, invasive op- eration, paralysis in bed, the use of corticosteroid therapy in acute stage. Conclusion The risk factors of NI in patients with Guillain-Barre syndrome are very complicated and some effective measures pointed to the possible impact factors should be pro- posed to prevent NI.