GRP及GRPR在结直肠癌、黏膜炎症中的表达及其意义

The expression and significance of GRP and GRPR in colorectal cancer and mucosal inflammation

目的 检测胃泌素释放肽（GRP）及其受体（GRPR）在结直肠癌、黏膜炎症中的表达及其意义.方法 选择本院2009年1月～2012年10月经病理诊断为结直肠癌患者60例的病理标本为研究组,选取同期病理诊断为黏膜炎性改变患者60例的病理标本为对照组,采用免疫组化方法,分别检测结直肠癌组织及黏膜炎性组织中GRP及GRPR的表达情况.结果研究组GRP及GRPR表达阳性率明显高于对照组,差异有统计学意义（P〈0.05）;研究组中结肠癌及直肠癌患者GRP及GRPR表达阳性率差异无统计学意义（P〉0.05）;结直肠癌Duks分期A、B期患者GRP及GRPR表达阳性率明显低于C、D期患者（P〈0.05）;低分化癌患者GRP及GRPR表达阳性率明显高于分化及高分化癌患者（P〈0.05）.结论 GRP及GRPR在结直肠癌中表达明显升高,并且随着肿瘤恶性程度增高,GRP及GRPR表达增加,可为临床结直肠癌诊断治疗提供新的方向.

Objective To explore the expression and significance of GRP and GRPR in colorectal cancer, mucosal inflammation. Methods Pathological specimens of 60 cases of patients who were diagnosed with colon cancer or colorectal cancer from January 2009 to October 2012 were selected as the study group, pathology specimens of 60 patients with inflammatory mueosal were selected as the control group, immunohistochemical methods were used to detect expression of GRP and GRPR in colorectal cancer tissues and mucous membrane inflammatory tissue. Results The GRP and GRPR expression of study group was significantly higher than control group （P 〈0.05）; In study group, GRP and GRPR expression of colon cancer and colorectal cancer was not significantly different （P〉 0.05）. GRP and GRPR expression of eoloreetal cancer staging of Duks A, B was significantly lower than C, D stage （P 〈0.05）; GRP and GRPR expression in poorly differentiated carcinoma was significantly higher than the well- differentiated carcinoma （P 〈0.05）. Conclusion GRP and GRPR expression in colorectal cancer is significantly increased, and with the degree of malignancy increasing, GRP and GRPR expression increasing, this can provide a new direction for clinical diagnosis and treatment of eolorectal cancer.