COPD稳定期患者血尿酸、尿酸/肌酐水平测定的临床意义

The detection and its clinical significance of serum uric acid and uric acid/creatinine in COPD patients

目的 检测慢性阻塞性肺疾病（COPD）患者血液中尿酸水平以及尿酸/肌酐比值的变化,并探讨其相关的临床意义.方法 收集我院2011年1月~2013年8月收治的COPD稳定期患者124例,参照FEV1值将COPD稳定期患者分为Ⅰ级（n=30）、Ⅱ级（n=32）、Ⅲ级（n=34）、Ⅳ级（n=28）四组.另取我院30例健康体检者作为正常对照.血尿酸测定使用酶比色法,血肌酐测定使用肌氨酸氧化酶法.结果 对照组和COPD组血尿酸的表达分别为（236.54±41.43）和（366.12±61.24）μmol/L,对照组和COPD组尿酸/肌酐的比值分别为（4.32±0.51）和（6.25±1.06）,COPD稳定期患者血尿酸的表达水平和尿酸/肌酐的比值均显著高于对照组（P〈0.01）.COPDⅠ、Ⅱ、Ⅲ和Ⅳ级患者血尿酸的表达水平分别为（274.62±53.54）、（356.27±60.26）、（403.52±76.45）和（421.61±77.35）μmol/L,其中Ⅳ级患者显著高于Ⅰ级（P〈0.01）和Ⅱ（P〈0.05）级患者,Ⅲ级患者显著高于Ⅰ级和Ⅱ级患者（P〈0.05）.Ⅱ级患者显著高于Ⅰ级患者（P〈0.05）,Ⅳ级和Ⅲ级患者之间无显著性差异（P〉0.05）.COPDⅠ、Ⅱ、Ⅲ和Ⅳ级患者尿酸/肌酐比值分别为（4.67±0.54）、（5.82±0.84）、（6.63±1.14）和（7.78±1.37）,各组之间具有显著性差异（P〈0.05）.结论COPD稳定期患者存在血尿酸表达水平的升高,尿酸/肌酐的比值可以用于COPD稳定期患者病变的评估.

Objective To investigate the changes of and its clinical significance serum uric acid and uric acid/creatinine in patients with chronic obstructive pulmonary disease （COPD）. Methods From Jan 2011 to Aug 2013,124 cases of COPD patients treated in our hospital were enrolled in this study. According to FEV1 values the patients were derided into grade I （n=30）, II （n=32）, III （n=34）, and IV （n=28） level. Another 30 healthy person were collected as a normal control. The expression of serum uric acid was detected by enzyme chromatometry. The expression of creatinine was detected by oxidation enzyme analyse. Results The serum uric acids were （236.54±41.43） and （366.12±61.24） umol/L in control and COPD group. The uric aeid/creatinine values were （4.32±0.51） and （6.25±1.06） in control and COPD group. Which was higher in COPD group than that in control group （/9〈0.01）. The expression of serum uric acid in I , II , III ,and IV group was （274.62±53.54）, （356.27±60.26）, （403.52±76.45）, and （421.61±77.35 ） umol/L. Which was higher in group IV than that in I group（P〈0.01 ）and group II （P〈0.05）,and in group III than that in group I and group II （P〈0.05）, and in group II than that in group I （P〈0.05）. There was no signicifant difference between group III and group IV（P〉0.05）. The uric acid/creatinine values in I , II, III and IV group were （4.67±0.54）, （5.82 ± 0.84）, （6.63 ±1.14）, and （7.78± 1.37）. There was signicifant difference among the four groups （P〈0.05）. Conclusion Stable COPD patients have elevated levels of uric acid,uric acid / creatinine ratio, and can be used to evaluate the lesions in patients with stable COPD.