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阿维A联合窄谱中波紫外线治疗寻常型银屑病的临床疗效观察 被引量:12

The clinical efficacy of Avi A joint narrowband UVB in treatment of psoriasis vulgaris
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摘要 目的 探讨阿维A联合窄谱中波紫外线治疗寻常型银屑病的临床疗效.方法选择2011年1月~2012年1月在我院进行治疗的寻常型银屑病患者80例为研究对象,随机分为治疗组和对照组各40例.对照组采用窄谱中波紫外线(Narrow-band,UVB)照射治疗,观察组同时联合阿维A口服,疗程4~8周,治疗8周结束后应用统计学方法对两组的疗效进行评价,并观察治疗期间的不良反应.结果 治疗8周结束后,观察组的总有效率达95%(38/40),明显高于对照组(95%vs75%,χ2=6.327,P〈0.05).观察组治疗后的PASI评分较对照组明显降低(3.15±0.49 分vs 9.36±0.73分,P<0.05).结论阿维A联合窄谱中波紫外线治疗寻常型银屑病疗效确切,值得推广和应用. Objective To investigate the clinical efficacy of Avi A joint narrow-band UVB in treatment of psoriasis vulgaris. Methods Selected 80 cases psoriasis vulgaris in our hospital for hospitalized treatment from January 2011 to January 2012 for this study,and they all were randomly divided into treatment group and control group 40 cases.The control group was given narrow-band ultraviolet(Narrow-band, UVB) irradiation treatment,the observation group on the base of the control group was given Avi A combined oral,treatment 4-8 weeks for a course,and after treatment 8 weeks,the efficacy were evaluated,and the adverse reactions were observed. Results After threatment eight weeks,the observation group's effective rate was 95%(38/40),was significantly higher than the control group (95% vs 75% ,X2= 6.327,P〈0.05).After treatment,the PASI score of the treatment group was significantly lower than the control group (3.15±0.49 vs 9.36±0.73 ,P 〈0.05). Conclusion Avi A joint narrowband UVB in treatment of psoriasis vulgaris has good efficacy, it is worthy of promotion and application.
出处 《中国现代医生》 2014年第6期68-70,共3页 China Modern Doctor
关键词 寻常型银屑病 阿维A 紫外线 窄谱 中波 Psoriasis Avi A Ultraviolet light Narrow spectrum Wave
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  • 1张建中.几种新的外用糖皮质激素[J].中国药物应用与监测,2005,2(5):30-33. 被引量:20
  • 2杨宝琦,赵娜,张福仁.银屑病光疗和光化学疗法的研究进展[J].中华皮肤科杂志,2005,38(3):195-197. 被引量:49
  • 3廖康煌,阎春林,王漪.日光反应性皮肤型的测定及其意义 [J].中华皮肤科杂志,1995,28(5):287-289. 被引量:101
  • 4郭静,王龙成,贾惠临.阿维A治疗银屑病的临床疗效观察[J].临床皮肤科杂志,2005,34(11):776-776. 被引量:17
  • 5Lebwohl M,Christopers E,Langley R,et al.An internation,randomized,double-blind,place-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis[J].Archpematol,2003,139(6):719.
  • 6Ozawam,Ferenczik,Kikuchi T,et al.312-nanometer ultroviolte blight (narrow-bamd uvB)indaces apoposis of T cell with in psoriatic lesions[J].JEXP Med,1999,184(4):711.
  • 7Leenutaphong V,Nimkulrat P,Sudtim S.Comparison of phototherapy two times and four times a week with low doses of narrow-band ultraviolet B in Asian patients with psoriasis[J].Photodermatol Photoimmunol Photomed,2000,16:202-206.
  • 8Lebwohl M,Christopers E,Langley R,et al.Aninternational,randomized,double-blind,placebo-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis[J].Arch Dermatol,2003,139:719-727.
  • 9Marks R, Barton SP, Shuttleworth D, et al. Assessment of disease progress in psoriasis[J]. Arch Dermatol, 1989, 125(2): 235-240.
  • 10Wiegand UW, Chou RC. Pharmacokinetics of acitretin and etretinate[J]. J Am Acad Dermatol, 1998, 39(2 Pt 3): S25-S33.

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  • 1王丽,马彦,王冬梅,马骏驰.阿维A治疗重症银屑病临床疗效与安全性评价[J].中国皮肤性病学杂志,2005,19(1):61-62. 被引量:33
  • 2冯峥,葛萍,李恒进,黎燕.银屑病患者血清TNFα浓度及其在皮损中的表达研究[J].军医进修学院学报,2005,26(2):81-83. 被引量:18
  • 3张学军.皮肤性病学[M].6版.北京:人民卫生出版社.2005:164.
  • 4Zhao L, Chen X,Cai L, et al. Randomized, double-blind, placebo -controlled, multiple -dose study of the safety, tolerability and pharmacokinetics of benvitimod, a candi- date drug for the treatment of psoriasis [J]. J Ctin Pharm Ther,2014,39(4) :418-423.
  • 5Tausend W,Downing C,Tyring S. Systematic review of interleukin-12,interleukin-17,and interleukin-23 path- way inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis:ustekinumab,briakinumab,tildrak- izumab,guselkumab,secukinumab,ixekizumab,and bro- dalumab |J1. J Cutan Med Surg,2014,18(3):156-169.
  • 6蔡莎莉,彭俊秋.PASI评分在银屑病护理观察中应用的效果评价[J].中国实用护理杂志,2013,29(z1):114.
  • 7Schneider LA, Hinrichs R, Scharffetter Kochanek K. Photother apy and photochemotherapy[J]. Clin Dermatol, 2008,26 (5) 464-476.
  • 8Karadag A S,Bilgili S G,Onder S,et al.Two cases of eczematid-like purpura of Doucas and Kapetanakis responsive to narrow band ultraviolet B treatment[J].Photodermatol Photoimmunol Photomed,2013,29(2):97.
  • 9孙建方,温海,郝飞,韩永智,曾学思,刘晓刚,周村建.阿维A治疗寻常性银屑病120例[J].中华皮肤科杂志,2008,41(3):204-205. 被引量:10
  • 10钟金宝,梁艳华,李仰琪,何伟强,李燕红,梁燕梅.窄谱中波紫外线对银屑病患者肿瘤坏死因子和白介素-2的影响及疗效[J].岭南皮肤性病科杂志,2008,15(4):211-213. 被引量:6

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