晚期胃肠道恶性肿瘤患者恶液质形成与肿瘤坏死因子-α和白介素-6浓度的关系

Relationship of dyscrasia formation and the concentration of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) of patients with advanced gastrointestinal cancer

目的探讨晚期胃肠道恶性肿瘤患者恶液质形成与肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)浓度关系。方法选择43例晚期胃肠道恶性肿瘤(实验组),检测血清TNF-α和IL-6浓度及营养参数,并随访半年。根据存活情况分为存活组与死亡组。另选择健康就诊者50例为对照组。结果实验组血清TNF-α和IL-6浓度明显高于对照组(P<0.01),BMI、TSF、MAC和ALB水平低于对照组(P<0.05或P<0.01)。血清TNF-α和IL-6浓度与营养参数BMI、TSF、MAC和ALB呈负相关(P<0.05或P<0.01)。存活组患者血清TNF-α和IL-6浓度低于死亡组(P<0.05)。结论晚期胃肠道恶性肿瘤患者营养状况明显恶化,且体内血清TNF-α和IL-6浓度明显升高,且其浓度越高,恶液质越明显,患者半年生存率越低。

Objective To discuss relationship between dyscrasia formation and the concentration of tumor necrosis factor-a（TNF-a） and interleukin-6 （IL-6） of patients with advanced gastrointestinal cancer. Methods Forty-three cases of patients with advanced gastrointestinal cancer （experimental group） were tested the concentration of serum TNF-a and IL-6, and the nutrition index as well. The patients in experimental group were divided into survival group and death group, 50 cases of healthy patients who saw a doctor at the same period were additionally selected as control group. Results The concentration of serum TNF-a and IL-6 of patients in experimental group was much higher than that in control group, and the BMI, TSF, MAC and ALB values in experimental group were much lower than those in control group （P〈0.05 or P〈0.01）. The serum TNF-a and IL-6 concentration were showed negative correlation with nutrition indexes of BMI, TSF, MAC and ALB （P〈0.05 or P〈0.01）. The serum TNF-a and IL-6 concentration was much lower in survival group than those in death group （P〈0.05）. Conclusion Nutrition status decreases in inadvanced gastrointestinal cancer, and the concentration of serum TNF-a and IL-6 obviously rises accompanied with the formation of dyscrasia and the fall of the half year survival rate.