不同剂量辛伐他汀治疗脑梗死的效果比较

Comparison of effect of different doses of simvastatin in treatment of cerebral infarction

目的 探讨不同剂量辛伐他汀治疗脑梗死的效果.方法将新入院脑梗死患者随机分成对照组、10 mg辛伐他汀组、20 mg辛伐他汀组、40 mg辛伐他汀组,比较不同组间血脂水平、脑血管狭窄条数、再发脑梗率、脑梗死体积恢复百分比及远期生活质量.结果 20 mg和40 mg辛伐他汀治疗组平均每人脑血管狭窄条数分别为（2.1±0.3）和（1.2±0.3）,低于对照组的（3.2±0.5）.20 mg和40 mg辛伐他汀治疗组患者脑梗死体积恢复百分比为（9.1±1.8）%和（11.2±1.9）%,高于对照组（6.3±1.7）%.20 mg及40 mg辛伐他汀治疗组MBI评分分别是（61.2±11.3）和（65.3±9.8）,QOL评分分别是（31.3±10.1）和（35.8±7.3）,均显著高于对照组（P＜0.05）.结论脑梗死患者口服20～40 mg辛伐他汀可以降低血脂水平,减少脑血管狭窄及梗死体积,改善患者远期预后.

Objective To investigate the effect of different doses of simvastatin in the treatment of patients with cerebral infarction. Methods The patients with cerebral infarction were randomly divided into the control group, 10 mg simvastatin group,20 mg simvastatin group and 40 mg simvastatin group. The blood lipids level, number of cerebral vascular stenosis, recurrent rate of cerebral infarction,percentage of cerebral infarction volume recovery and long-term quality of life of different groups were compared. Results The average number of cerebral vascular stenosis of the 20mg and 40 mg simvastatin group were （2.1±0.3） and（1.2±0.3） per person, respectively, which were lower than that of the control group （3.2±0.5）.The percentage of cerebral infarction volume recovery of the 20 mg and 40 mg simvastatin group were （9.1±1.8）% and （11.2±1.9）%, respectively ,which were higher than that of the control group （6.3±1.7）%. The MBI score of the 20mg and 40rag simvastatin group were （61.2±11.3） and （65.3±9.8） respectively, and QOL score were （31.3±10.1） and （35.8±7.3） respectively,which were significantly higher than that of control group. Conclusion Taking orally 20-40mg simvastatin for patients with cerebral infarction can lower the blood lipids level, reduce the cerebral vascular stenosis and infarction volume, improve the long-term prognosis of patients.