肾病综合征患者胆碱酯酶与白蛋白比值临床意义的探讨

Clinical significance of cholinesterase and albumin ratio in nephrosis syndrome patients

目的 探讨血清胆碱酯酶（CHE）与血清白蛋白（ALB）比值检测在肾病综合征患者中的临床应用价值.方法对抚顺市中心医院2013年1～9月54例肾病综合征患者和71例排除肝脏疾病、心脏疾病、外科手术的患者及其他肾脏疾病的体检人员（对照组）进行外周血CHE、ALB检测,同时检测肾病综合征患者尿蛋白.结果肾病综合征患者中CHE、ALB、CHE/ALB比值与对照组组间比较差异有统计学意义（P ＜ 0.05）;CHE/ALB对肾病综合征的诊断阳性率98.1%,并且与患者尿蛋白的量呈正相关（r=0.5687）.结论肾病综合征患者CHE/ALB比值增高可以做为肾病综合征的诊断标准,并反映肾病综合征的病情危重程度.

Objective To investigate the clinial significance of serum cholinesterase （CHE） and serum albumin （ALB） ratio detection for the diagnosis in nephrosis syndrome disease. Methods Collected 54 cases with nephrotic syndrome and 71 cases exclude liver disease, heart disease, kidney disease patients and other medical staff surgery for control group in Fushun central hospital from January to September 2013. The levels of serum CHE, ALB, CHE/ALB ratio were measured in patient group and healthy control group, simultaneously detected proteinuria in nephrotic syndrome patients. Results The levels of CHE, ALB, CHE/ALB in nephrotic syndrome patients had a statistically significant difference compared with the control group （P 〈 0.05）. Positive rate of diagnosis of nephrotic syndrome by CHE/ALB was 98.1%, and CHE/ALB was relevant with the patient＇s urine protein （r = 0.5687）. Conclusion CHE/ALB ratio increase can be used as a diagnostic criteria for nephrotic syndrome, and react the severity of illness.