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血管内皮生长因子在大肠癌诊治中的应用研究 被引量：4

Significance of Vascular Endothelial Growth Factor in Diagnosis of Coloretal Cancer
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摘要 Objective To determine whether the serum vasular endothelial growth factor(VEGF) level could be used as a predictor of recurrence and disease progression in patients with colorectal cancer.Methods Serum levels of VEGF in 30 healthy controls,85 patients with colorectal cancer and 21 patients between half and 4 years after colorectal cancer operation were measured with a sandwich enzyme immunoassay(ELISA),and the results were analyzed.Results Significant differences in the VEGF level were observed between controls and the patients with Duke′s A stage( P <0.01).Whereas there was no significant difference between healthy controls and high differentiation cancers( P >0.05).The VEGF level was significantly associated with Duke′s stage of the patients( P <0.05).Patients with lymph node metastasis(Duke′s C) had higher VEGF levels than those without it(Duke′s B, P < 0.01 ).There were significantly differences between patients with recurrence and no recurrence after surgical resection( P <0.01).Conclusion The results of this study suggest that the serum VEGF level is a useful marker for colorectal cancer and the elevation of serum VEGF level may be used as a new independent predictor of recurrence and disease progression. Objective To determine whether the serum vasular endothelial growth factor(VEGF) level could be used as a predictor of recurrence and disease progression in patients with colorectal cancer.Methods Serum levels of VEGF in 30 healthy controls,85 patients with colorectal cancer and 21 patients between half and 4 years after colorectal cancer operation were measured with a sandwich enzyme immunoassay(ELISA),and the results were analyzed.Results Significant differences in the VEGF level were observed between controls and the patients with Duke′s A stage( P <0.01).Whereas there was no significant difference between healthy controls and high differentiation cancers( P >0.05).The VEGF level was significantly associated with Duke′s stage of the patients( P <0.05).Patients with lymph node metastasis(Duke′s C) had higher VEGF levels than those without it(Duke′s B, P < 0.01 ).There were significantly differences between patients with recurrence and no recurrence after surgical resection( P <0.01).Conclusion The results of this study suggest that the serum VEGF level is a useful marker for colorectal cancer and the elevation of serum VEGF level may be used as a new independent predictor of recurrence and disease progression.
作者 孟冬娅 薛文成 胡晓芳 胡华 罗军 王一楠
机构地区 沈阳军区总医院检验科
出处 《实用癌症杂志》 2001年第1期46-48,共3页 The Practical Journal of Cancer
关键词 大肠癌 诊断 治疗 血管内皮生长因子 肿瘤标志物 Vascular endothelial growth factor(VEGF) Colorectal neoplasms Tumor marke@
分类号 R735.34 [医药卫生—肿瘤]
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参考文献10

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同被引文献36

  • 1潘继存,刘亚民.透明质酸酶与肿瘤生长和转移[J].齐鲁肿瘤杂志,1996,3(2):145-146. 被引量：2
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  • 3Miyake H,Hera I,Yamanaka K,et al. Elevation of serum level of vascular endothelial growth factor as a new predictor of recurrence and disease progression in patients with superficial urothelial cancer[ J]. Urology, 1999,53:302 - 307.
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  • 6Ohno M,Nakamura T,Kunimoto Y,et al.Lymphagenesis correlates with expression of vascular endothelial growth factor-C in colorectal cancer[J].Oncol Rep,2003,10(4):939-43.
  • 7Ueno H,Mochizuki H,Hashiguchi Y,et al.Risk factors for an adverse outcome in early invasive colorectal carcinoma[J].Gastroenterology,2004,127(2):385-94.
  • 8Tominaga K,Nakanishi Y,Nimura S,et al.Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma[J].Dis Colon Rectum,2005,48(1):92-100.
  • 9Terhi Karpanen,Kari Alitalo.Lymphatic vessels as targets of tumor therapy?[J].The Journal of Experimental Medicine,2001,194(6):37-42.
  • 10Kitajima K,Fujimori T,Fujii S,et al.Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma:a Japanese collaborative study[J].J Gastroenterol,2004,39(6):534-43.

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实用癌症杂志
2001年 第1期

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