老年人退行性心瓣膜病与超氧化物歧化酶、丙二醛的关系──附72例报告

Relationship between degenerative valvular disease and superoxide dismutase or malondialdehyde in elderly.

目的:探讨老年人退行性心瓣膜病与超氧化物歧化酶(SOD)、丙二醛的关系。方法:对72例老年人退行性心瓣膜病(CVD)患者的临床资料进行分析,比较其入院治疗前后SOD和丙二醛的情况,并检测31名健康人血清SOD、丙二醛水平作为对照。结果:退行性心瓣膜病主要累及二尖瓣和主动脉瓣,SOD水平明显低于正常组(>0.01),而丙二醛水平则显著高于正常组(<0.001)。伴有心力衰竭的54例病人的SOD及丙二醛水平,前者治疗前与治疗后比较明显上升(<0.001),后者则明显下降(<0.01),显示与病情严重程度呈平行关系。影响SOD水平的主要因素为左心室腔扩大,而左心房扩大对丙二醛水平影响最大。结论:SOD、丙二醛水平检测可作为老年人退行性心瓣膜病时反映心肌细胞受损严重程度的较好指标。

Objective:To study the relationship between serum superoxide dismutase SOD or malondialdehyde MDA and degenerative valvular disease in the aged. Methods:Thirty one cases of NC group normal and 72 degenerative valvular disease in the agedCVD group were enrolled in this retrospective study. Results:Mitral and aortic valve were among the most common valves to be involved. SOD88±28 μU/L was significantly lower and MDA 5.3±2.7μU/L was higher in patients with heart dilation and congestive heart failure than those in the normal. Their levels were correlated with the severity of diseases. Conclusion: SOD and MDA are valuable indicators of myocardial lesions for elderly patients with degenerative valvular diseases.