肝癌特异性γ-谷氨酰转肽酶、铁蛋白和脂质结合唾液酸联合检测诊断肝癌的价值

Clinical values of serum HSB,SFn and LSA Analysis in Diagnosis of Hepatocellular Carcinoma

目的 探讨肝癌特异性γ 谷氨酰转肽酶、铁蛋白和脂质结合唾液酸浓度改变在肝癌诊断与鉴别中的临床价值。方法 分别定量检测了肝癌、慢性肝病和肝外肿瘤患者血清中肝癌特异性GGT同工酶区带 (HSB)、铁蛋白 (SFn)和脂质结合唾液酸 (LSA)浓度。结果 肝癌组血清HSB浓度TAE前明显异常 ,同时也高于慢性肝炎、肝硬化和肝外肿瘤病人 (P <0 0 0 1) ;SFn和LSA水平肝癌组明显高于慢性肝病患者 ,但与其他肿瘤无鉴别价值 ;肝癌组HSB、SFn和LSA的阳性率分别为10 0 %、5 3 3 %和 6 7 8%。结论 HSB定量和定性检测均优于SFn和LSA的浓度分析 。

Objectives To investigate the clinical values of three serum marker level alteration in diagnosis and differential diagnosis of primary hepatocellular carcinoma (PHC).Methods The hepatoma specific band(HSB) activities of serum GGT,the levels of serum ferritin (SFn) and lipid associated sialic acid (LSA) were quantitated in different patients with liver diseases.Results The concentrations of HSB in patients with PHC (before transcatheter arterial embolization)increased significantly in comparison with chronic liver diseases and other tumors ( P <0 001).The concentrations of SFn and LSA in PHC were significantly higher than those in chronic liver diseases,but no differentiation was found between PHC and other tumor groups.The incidence of HSB,SFn and LSA in PHC group was 100%,53 3% and 67 8%,respectively.Conclusion The quantitative analysis of HSB activities of GGT is superior to that of SFn and LSA.The combined detection of several markers was helpful to diagnosis and differential diagnosis of PHC.