TCD结合屏气试验评价 Hhcy者脑血管反应性

The evaluation of cerebrovascular reactivity by TCD combined with breath holding test

目的：评价高同型半胱氨酸血症者脑血管反应性.方法：高同型半胱氨酸血症者42例（年龄23～65岁,男24例,女18例）,正常人群50例（年龄20～68岁,男29例,女21例）,两组间年龄差异及性别比例无统计学意义.嘱托受试者平静呼吸5～10min后屏气25s,分别记录屏气前后MCA平均血流速度Vm及搏动指数PI值.并计算其变化值及变化率.结果：高同型半胱氨酸血症组平均血流速度Vm较对照组增快（P＜0.01）,搏动指数PI高于对照组（P＜0.05）.高同型半胱氨酸血症者组平均血流速度Vm变率为低于对照组,差异有统计学意义（P＜0.01）.结论：①高同型半胱氨酸血症者脑血管反应性降低.②TCD检查可以为高同型半胱氨酸血症者早期防治提供理论依据.

Objective. To evaluate hyperhomocysteinemia cerebral vascular reactivity. Methods. There were 42 cases in Hyper homocysteinemia group （age 23-65 years, 24 males, and 18 females）, 50 cases of nor- mal people （age 20-68 years old, male 29, female 21）. The differences of age and sex ratio in two groups have no statistically significance. We asked the subjects to hold breath 25s after breath 5-10 minutes. We recorded average flow velocity Vm of MCA and pt, lsatility index PI respectively before and after breath hold, then we calculated the change value and change rate. Results： The average blood flow velocity of Vm in Hyper homocysteinemia group increased faster than that in control group （P 〈 0.01）. Pulsatility index and resistance index of RI are higher than those in control group （P 〈 0.05）. Hyper homocysteinemia group average blood flow velocity of Vm was lower than that in the control group. The difference was statistically significant （P 〈 0.01）. Conclusion： The reactivity of Hyper homocysteinemia cerebral vascular reduced. TCD examina- tion can provide theoretical basis for homocysteine early prevention.