217例病毒性肝炎患者血浆维生素E水平分析

Plasma levels of vitamin E in 217 cases of viral hepatitis patients

目的 为了解肝病患者体内维生素E(VE)水平及其与病情发展变化的关系。方法 用荧光法及硫代巴比妥酸(TBA)反应法检测 2 17例各型病毒性肝炎患者血浆VE水平及丙二醛 (MDA)含量 ,动态观察急、慢性肝炎 ,重型肝炎血浆VE与MDA、肝功能变化的关系。结果 各型肝炎患者血浆VE水平均显著降低 ,病情越重者VE水平越低 ,急性肝炎患者血浆VE水平随肝功能恢复逐渐复常 ,慢性肝炎恢复期VE水平较急性期提高 ,但仍低于健康人 ,重型肝炎恶化、死亡病例VE持续于低水平 ,与血清胆红素呈负相关。

Objective To investigate the possible relationship between the vitamin E(VE) contents in the plasma and development of hepatosis.Methods VE and malondialdehyde(MDA) contents in 217 cases infected by various types of viral hepatitis were measured by means of fluorescence and TBA.Moreover,the relationship between both of the contents and the alteration of liver function was observed dynamically.Results The plasma levels of VE in all cases were decreased obviously.Interestingly,lower the contents of VE were,more severity the disease was.Howevey,the levels of VE recovered step by step when the liver function return to normal in the acute hepatitis cases.Unfortunately,the levels in the chronic hepatitis cases were higher in the recovering phase than in the acute phase,but still lower than normal.Moreover,VE kept low levels and showed a negative relationship to the bilirublin in both worsening and dying cases.Conclusion To observe the VE contents is helpful to the clinical evaluation of the hepatosis progress and prognosis.