米非司酮与去氧孕烯炔雌醇治疗功能失调性子宫出血的疗效比较

The Curative Comparison of Mifepristone and Desogestrel Ethinylestradiol in Treating Dysfunctional Tonal Uterine Bleeding

目的:观察米非司酮与去氧孕烯炔雌醇治疗功能失调性子宫出血的临床疗效。方法:将80例功能失调性子宫出血患者随机分为观察组和对照组,每组40例。观察组接受去氧孕烯炔雌醇治疗,对照组接受米非司酮治疗。两组均以连续用药21 d为1个疗程,持续治疗6个疗程后观察疗效。结果:观察组和对照组总有效率分别为97.5%和85.0%,差异有统计学意义(P<0.05)。两组治疗后FSH和LH无明显改变,P和E2均明显降低,与治疗前比较差异有统计学意义(P<0.05),治疗后两组比较差异具有统计学意义(P<0.05)。结论:米非司酮和去氧孕烯炔雌醇均能有效的治疗功能失调性子宫出血,但去氧孕烯炔雌醇的治疗效果更佳。

Objective：To observe the clinical curative effect of mifepristone and desogestrel ethinylestradiol for the treatment of dysfunctional tonal uterine bleeding.Method：80 patients with dysfunctional uterine bleeding were randomly divided into observation group and control group,40 cases in each group. Observation group received desogestrel ethinylestradiol treatment,control group treated with mifepristone.Both groups to 21 days of continuous medication for a period of treatment,continuous observation curative effect after the treatment of six course.Result：The observation group and control group total effective rate were 97.5%and 85.0%,the difference statistically significant（P〈0.05）. FSH and LH in two groups after treatment had no obvious change,E2 and P were significantly reduced,there were statistically significant difference compared with before treatment（P〈0.05）,there were statistical significance after treatment（P〈0.05）. Conclusion：Mifepristone and desogestrel ethinylestradiol are effective in the treatment of dysfunctional uterine bleeding,but the effect of desogestrel ethinylestradiol is better.