中药复方心脉通胶囊的抗心肌缺血疗效与机制

Anti-Myocardial Ischemia Effect ant Its Mechanism of Traditional Chinese Medicine Composite Xinmaitong Capsule

【目的】探讨中药复方心脉通胶囊对缺血性心脏病的治疗作用及其作用机制。【方法】 6 0例冠心病心肌缺血患者随机分为心脉通胶囊组 (30例 ,常规西药加心脉通胶囊治疗 )与对照组 (30例 ,单用常规西药治疗 ) ,观察治疗前后临床症状计分、心肌缺血总负荷 (TIB)、血浆内皮素 (ET)、一氧化氮 (NO)和血清超氧化物歧化酶 (SOD)、丙二醛 (MDA)的变化。【结果】治疗后两组临床症状计分、TIB、MDA均显著下降 (P <0 .0 5 ) ,而心脉通胶囊组下降幅度明显大于对照组 (P <0 .0 1) ,心脉通组ET显著下降 (P <0 .0 1) ,但对照组下降不明显 (P >0 .0 5 ) ;两组治疗后NO、SOD明显上升 (P <0 .0 5 ) ,而心脉通组上升幅度显著高于对照组 (P <0 .0 1)。【结论】心脉通胶囊有良好抗心肌缺血作用 ,其作用机制与血管内皮保护效应及抗脂质过氧化损伤密切相关 ,加用心脉通胶囊治疗缺血性心脏病比单用西药效果好。

Objective To assess the effects of traditional Chinese medicine composited Xinmaitong (XMT) capsule on treating ischemia cardiac disease. Methods Sixty coronary heart disease patients with myocardial ischemia were divided randomly into two groups. XMT group (30 cases) was treated with XMT and western medicine, and control group (30 cases) with western medicine. The changes of the scores of clinical symptoms, the total ischemia burden (TIB), the plasma endothelin (ET), the nitric oxide (NO), the super oxide dismutase (SOD), and the malonyldialdehyde (MDA) levels were observed before and after treatment. Results After treatment with XMT, the scores of clinical symptoms, TIB, ET and MDA levels were significantly decreased (P<0.01), the levels of NO and SOD were significantly increased (P<0.01) in XMT group. Comparing with control group, these changes were statistically different (P<0.01). Conclusions XMT capsule can act against myocardial ischemia effectively, one of the mechanisms of which is protecting the function of vascular endothelium and resisting lipid peroxidation injury. The effect of adding XMT capsule on conventional treatment with western medicine was better than that with western medicine only.