食管癌血管生成与淋巴结转移的关系

The correlation between tumor angiogenesis and lymph node metastasis in esophageal cancer.

目的 探讨食管癌血管生成与淋巴结转移的关系。方法 采用免疫组织化学的方法检测了 1994～ 1995年手术切除的 5 0例食管癌病人石蜡标本中微血管密度和血管内皮生长因子及其受体蛋白的表达。其中有食管旁淋巴结转移者 18例 ,胃左动脉旁淋巴结转移 15例。光镜下行 MVD、VEGF、F1t、KDR蛋白表达细胞的计数。结果 食管旁和胃左动脉旁淋巴结转移组的微血管密度 (MVD)、血管内皮生长因子 (VEGF)、血管内皮生长因子受体 (F1t、KDR)蛋白表达均高于未转移组。结论 食管癌中 MVD、VEGF、F1t、KDR蛋白表达与肿瘤转移行为密切相关 ,有可能作为判定肿瘤生物学行为、转移潜能及预后的指标。

Objective To study the relationship between tumor angiogenesis and lymph node metastasis in esophageal cancer.Methods [WT5”BZ]Angiogenesis was assessed by the microvessel density(MVD) and the expressions of vascular endothelial growth factor(VEGF),fms-like tyrosine(F1t),kinase insert domain-containing receptor(KDR) using immunohistochemical staining.Paraffin-embedded specimens from 50 esophageal cancer patients who under went mastectomy from 1994 to 1995 were studied.Eighteen patiens had histologically proved positive eosphageal lymph node,fifteen patients had positive lymph node of stormach artery microvesels,and the VEGF,F1t,KDR positive stained cancer cells were counted with light microscope.Results The protein expression was higher in the group of positive lymph node than in the group of negative lymph node.Conclusion MVD and the expression of VEGF,F1t,KDR are highly correlated with metastasis in esophageal cancer,which may serve as a parameter for determining tumor biological behaviour, metastatic potential and prognosis.