摘要
微小RNA(miRNAs)是一组在转录后水平上调节基因表达的非编码RNA分子,通常结合到mRNA分子上导致靶mRNA降解或翻译抑制。microRNA-130(miR-130)包括miR-130a和miR-130b。研究发现,miR-130在多种机制调控下,在一些肿瘤中发挥癌基因作用,而在另一些肿瘤中发挥抑癌作用,并且与多种肿瘤化疗耐药性有关。本文就miR-130在肿瘤中的作用做一综述。
MicroRNAs （miRNAs） are short non-coding RNA molecules those regulate post-tran- scriptional gene expression. MiRNA will bind to mRNA resulting in target mRNA degradation or translational repression. Researches confirm that the microRNA-130（miR-130） family,which con- sists of miR-130a and miR-130b,correlates with tumor genesis,metastasis and multiple drug re- sistance,and is regulated by various mechanisms. We review the relationship between miR-130 and neoplasms.
出处
《中国肿瘤》
CAS
2014年第2期136-140,共5页
China Cancer
