心脉隆对心力衰竭患者血清MMP-9的影响

THE EFFECT OF XINMAILONG ON MATRIX METALLOPROTEASES-9 IN PATIENTS WITH CONGESTIVE HEART FAILURE(CHF)

目的研究心脉隆对充血性心力衰竭(CHF)患者基质金属蛋白酶9(MMP-9)的影响。方法选择60例CHF患者,将CHF组患者随机分为二组,心脉隆组(A组)和常规治疗组(B组)各30例,二组患者在治疗前后分别测定血清MMP-9的浓度,并与临床症状的改善及彩色多普勒检测结果进行对照。结果 A组治疗后血清MMP-9水平低于治疗前,二者比较差异有统计学意义(P<0.05);治疗后血清MMP-9水平A组低于B组,二者比较差异有统计学意义(P<0.05);A组治疗后LVEF、6min步行试验(6MWT)高于治疗前,心率低于治疗前,二者比较差异有统计学意义(P<0.05)。治疗后A组LVEF、6MWT高于B组,心率低于B组,二者比较差异有统计学意义(P<0.05)。结论心脉隆可降低CHF患者血清MMP-9水平,从而改善左室重构及心脏功能。

Objective To investigate the effect of Xinmailong injection on matrix metalloprotease - 9 （MMP- 9） for patients with congestive heart failure （CHF）. Methods A total of 60 CHF patients with CHF were randomly divided into two groups.. Xinmailong injection treatment group （group A,n = 30） and regular treatment group （group B,n = 30）. The serum levels of MMP-9 were detected be- fore and after the treatment, and then compared it with clinical symptom and Doppler results. Results Compared with prior treatment in group A, the serum levels of MMP - 9 and heart rate were de- creased, LVEF and 6MWT were increased in posttreatment. After treatment, the serum levels of MMP - 9 and heart rate in group A were observably lower than that in group B, but whose LVEF and 6MWT were increased than group B, and all the deference had statistically significance（P^0.05）. Conclusion Xinmailong injection can decrease the serum levels of MMP-9 of the CHF patients, and reverse the left ventricular remodeling and improve the cardiac function.