血常规在儿童巨细胞病毒活动性感染辅助诊断中的价值研究

RESEARCH ABOUT BLOOD ROUTINE'S ROLE ON AIDED DIAGNOSIS OF CHILDREN'S ACTIVE CYTOMEGALOVIRUS INFECTION

目的探讨血常规在儿童巨细胞病毒活动性感染辅助诊断中的价值,为降低巨细胞病毒活动性感染漏诊率找出一条新的途径,以利于患者的进一步确诊和规范治疗。方法对在我科诊治的173例疑似巨细胞病毒导致的下呼吸道感染患儿行尿HCMV-DNA检测,根据检测结果分为阳性组和阴性组,对二组患儿的血常规进行统计学分析,比较二组间差异有无统计学意义。结果 173例患儿中尿HCMV-DNA检测结果为阳性的有108例、阴性65例,阳性组与阴性组的血红蛋白、白细胞计数、淋巴细胞计数、血小板计数差异均有统计学意义(P<0.01),二组红细胞计数、中性粒细胞数差异无统计学意义(P>0.05)。结论儿童巨细胞病毒活动性感染常表现为血红蛋白降低、白细胞升高、淋巴细胞升高、血小板升高等"三高一低"表现,因此,血常规可以作为儿童巨细胞病毒活动性感染的辅助诊断依据。

Objective To discuss the role of blood routine in auxiliary diagnosis of children＇s active cy- tomegalovirus infection, and to find a new way of reducing the misdiagnosis rate for further definitive diagnosis and treatment. Methods Urinary HCMV - DNA assays were performed on 173 children with suspected lower respiratory tract infection with cytomegalovirus and then classified them into pos- itive group and negative group according to the assay result. A statistical analysis of blood routine was made to sure whether the significant difference between two groups. Results Among 173 children, 108 were positive in urinary HCMV- DNA assay and 65 were negative. The differences in hemoglo- bin, white blood cell count, lymphocyte count, platelet count between two groups were of highly sta- tistical significance（P（0.01）. The differences in red blood cell count and neutrophil count were not statistically significant （P^0. 05）. Conclusion Children＇s active cytomegalovirus infection is often manifested as follows： Decrease in hemoglobin, increase in white blood cell count, lymphocyte count and platelet count. So, blood routine can be taken as aided diagnostic evidence for children＇s active cy- tomegalovirus infection.