二种手术方式治疗非小细胞肺癌110例疗效分析

CLINICAL COMPARISON OF TWO DIFFERENT SURGICAL PROCEDURES ON NON-SMALL CELL LUNG CANCER

目的探讨肺癌袖状切除术与全肺切除术二种手术方式在非小细胞肺癌治疗中的疗效差异。方法将110例确诊为非小细胞肺癌的患者随机分为观察组(袖状切除术组)和对照组(全肺切除术组),各55例,对二组患者的术后相关情况进行追踪比较分析。结果观察组术后肺功能测定[第一秒用力呼气量(FEV1)、用力肺活量(FVC)及自测呼气峰值流速(PEF)]明显优于对照组(P<0.05);观察组术后并发症发生率为12.73%,对照组为30.91%,二组比较差异有统计学意义(P<0.05);观察组术后随访第1、3、5年生存率分别为83.6%、60%、47.3%,对照组分别为65.5%、40%、27.3%,二组术后第1、3、5年生存率比较差异均有统计学意义(P<0.05)。结论袖式切除术治疗非小细胞肺癌能有效改善患者术后肺功能,降低术后并发症发生率及病死率,延长远期生存率,疗效优于全肺切除术,值得推广运用。

Objective To observe the clinical effect of sleeve resection and pneumonectomy on non- small cell lung cancer（NSCLC）. Methods Totally 110 patients with NSCLC were divided randomly into treatment group （sleeve resection group, 55 cases） and control group （pneumonectomy group, 55 eases）. Postoperative situation of two groups were observed. Results The respiratory function tests （FEV1, FVC, PEF） of treatment group were significantly superior to that of control group, the inci- dences of complications of treatment group （12. 73%） was lower than that of control group （30.91% ）, and all the one- year, three- year, five- year survival rates of treatment group （83.6%, 60%, 47.3%） were higher than that of control group （65.5%, 40%, 27.3%） （all （P〈0.05）. Con- clusion The clinical effect of sleeve reseetion on NSCLC is high - performance and low- complication incidences, it can extend the long- term survival rate obviously. Therefore, the clinical effect of sleeve resection is superior to that of pneumoneetomy on NSCLC, and it is worth popularizing.