摘要
陷窝是细胞膜表面富含胆固醇的内陷微区，参与多种生理学过程。陷窝蛋白-1是参与构成陷窝的重要膜蛋白，通过与多种信号蛋白结合而发挥生物学效应。在脑血管病的病理生理学过程中，陷窝蛋白-1参与维持血脑屏障的完整性和动脉粥样硬化斑块的稳定性，而且具有调控炎性介质释放和神经保护作用。文章对陷窝蛋白-1与脑血管病关联性的研究进展进行了综述，旨在为临床治疗提供新的思路。
Caveolae are cholesterol-rich pits on the surface of cell membrane, and participate in various physiological processes. Caveolin-1 is an important membrane protein constituting caveolae. It exerts biological effects through binding a variety of signaling proteins. In the pathophysiological processes of cerebrovascular disease, caveolin-1 participates in maintaining the integrity of blood-brain barrier and stability of atherosclerotic plaques, and has regulating the release of inflammatory mediators and neuroprotection. This article reviews the associated advances in research on the correlation between caveolin-1 and cerebrovascular disease in order to provide a new idea for clinical therapy.
出处
《国际脑血管病杂志》
北大核心
2014年第1期75-78,共4页
International Journal of Cerebrovascular Diseases
关键词
陷窝蛋白1
脑梗死
脑缺血
脑出血
血脑屏障
Caveolin 1
Brain Infarction
Brain Ischemia
Cerebral Hemorrhage
Blood-Brain Barrier
