博舒替尼合成路线图解

Graphical synthetic routes of bosutinib

目的:通过分析已有的博舒替尼合成方法,找到适合工业化生产的路线。方法:对博舒替尼的合成路线进行总结。结果与结论:路线4原料易得,条件温和,总收率较高,更加适于工业化生产。

Objective： To review the existing synthetic routes of bosutinib, and find the suitable route for industrialization. Methods ： We summarized the various synthetic processes of bosutinib. Results and Conclusion ： The route 4, with the moderate reaction conditions and a high total yield, shows more favorable in manufacturing scale.