精神分裂症首次发病未治疗患者静息态下局部脑区自发活动的研究

Study of resting-state spontaneous activity of local brain in first episode and untreated patients with schizophrenia

目的探讨精神分裂症首次发病未治疗患者静息态下局部脑区自发活动的情况:方法:利用低频振幅(ALFF)方法,对27例首次发病未治疗的精神分裂症患者(患者组)进行静息状态下功能磁共振(fMRI)扫描,对影像学数据进行ALFF方法处理,结果与22名年龄、性别及受教育程度相匹配的健康对照者(正常对照组)比较。结果:与正常对照组相比,患者组ALFF显著增高的脑区是运动前区、辅助运动区和眶额回;ALFF显著降低的脑区是楔前叶、后扣带回、内侧前额叶和角回(P<0.05,Alphaism矫正)。结论:精神分裂症首次发病未治疗患者在静息态下运动前区、辅助运动区、眶额回、楔前叶、后扣带回、内侧前额叶和角回的局部脑区自发活动异常,这些异常脑区可能有助于解释精神分裂症的病理机制。

Objective：To explore the resting-state spontaneous activity of localized brain in first episode and untreated patients with schizophrenia. Method：Using the method of amplitude of low frequency fluctuation （ALFF）,the 27 first-episode and untreated patients with schizophrenia（case group）carry on resting-state functional magnetic resonance imaging scans （fMRI） and the fMRI data were was ALFF approach,and then results was compared with 22 sex,age-and eduate-matched healthy controls（normal control group）.Results：Compard with the normal control group,ALFF significantly higher brain areas in the case group were premotor area,supplemental motor area and orbitofrontal lobe;and ALFF significantly decreased brain areas were precuneus,posterior cingulate cortex,medial prefrontal lobe and angular gyrus （P〈0.05,Alphaism corrected）.Conclusion：There are ubnormal resting state-spontaneous activity localized brain in first episode and untreated patients with schizophrenia such as remotor area,supplemental motor area,orbitofrontal lobe,posterior cingulate cortex,medial prefrontal lobe and angular gyrus.These abnormal brain regions may help explain the pathogenesis of schizophrenia.