龙葵葶苈汤治疗肺癌大量恶性胸腔积液及对患者细胞免疫功能的影响

The Effect of Morel TingLi Decoction on Lung Cancer Patients with Malignant Pleural Effusion and on Cellular Immune Function

目的观察龙葵葶苈汤内服联合顺铂(DDP)胸腔内灌注化疗治疗肺癌大量恶性胸腔积液的临床疗效及其对患者免疫功能的影响。方法将患者44例随机分为实验组(葵葶苈汤口服+DDP胸腔内灌注)21例和对照组(单纯DDP胸腔内灌注)23例,治疗3周后比较两种方案治疗恶性胸腔积液的临床疗效、对患者细胞免疫功能的影响及其DDP灌注化疗的毒副反应。结果实验组客观有效率(ORR)为85.71%,对照组为43.48%;实验组治疗后CD3、CD4、及CD8阳性T细胞百分比明显升高(P<0.05),而对照组无明显变化(P>0.05);实验组胃肠道反应及血液学毒性总发生率为19.04%,对照组为60.87%。结论龙葵葶苈汤内服联合DDP胸腔内灌注可显著提高肺癌大量恶性胸腔积液的临床疗,降低化疗不良反应发生率,提高患者机体的细胞免疫功能。

Objective： To explore the clinical efficacy of Morel TingLi decoction combined cisplatin （DDP） in- trathoracic perfusion chemotherapy in the treatment of malignant pleural effusion in lung cancer patients and its influence on the immune function. Methods： 44 patients with lung cancer of pleural effusion were recruited in our hospital from Aug 2011 to Jul 2013. The random number table method was used to divide 44 patients into experi- mental group （kwai TingLi decoction oral ＋ DDP intrathoracic perfusion） （21 cases） and control group （simple DDP intrathoracic perfusion）（23 cases）. 3 weeks after the treatment,the clinical efficacy,side reaction,and im- mune function of the two groups were compared. Results： The objective response rates were 85.71% and 43.48% in treatment group and control group respectively. The figure of treatment group was much higher than that of control group （P〈 0.05）;CD3,CD4,and CD8 positive T cell percentage increased significantly in the treatment group compared with control group （P〈 0.05）. The gastrointestinal tract reaction and toxicity of hematology total incidence were 19.04% and 60.87% in treatment group and in control group respectively. The figure in treatment group was significantly lower than that in control group （P〈 0.05 ）. Conclusion： Morel TingLi decoction combined with DDP intrathoracic perfusion can significantly improve the clinical effect of lung cancer patients with plenty of malignant pleural effusion,reduce the incidence of adverse reaction of chemotherapy,and enhance the cellular immune function.