格列美脲片治疗2型糖尿病的效果与安全性分析

Efficacy and safety of glimepiride tablets in treatment of type 2 diabetes mellitus

目的观察格列美脲片治疗2型糖尿病的效果与安全性。方法选择本院126例2型糖尿病患者,随机分为格列美脲组66例和格列吡嗪组60例,分别给予格列美脲和格列吡嗪治疗,4周后测定空腹血糖(FPG)、餐后2 h血糖(2h PG)、空腹血C肽、餐后2 h血C肽和糖化血红蛋白(HbA1c)含量,检测胰岛素抵抗指数(HOMA-IR)和胰岛β细胞功能指数(HOMA-β),记录发生低血糖反应的次数。结果治疗后两组FPG和HbA1c均显著下降,格列美脲组下降更明显;两组患者空腹血C肽、餐后2 h血C肽水平都升高,格列美脲组患者血C肽升高更明显,低血糖反应次数明显减少;而且格列美脲组HOMA-IR下降明显,HOMA-β功能升高显著(P<0.05)。结论格列美脲片治疗2型糖尿病效果较好,能减少低血糖反应,安全性好,患者用药依从性高,在改善胰岛β细胞功能方面更有优势。

Objective To explore the effect and safety of glimepifide tablets in treatment of type 2 diabetes mellitus. Methods 126 cases of patients with type 2 diabetes mellitus were randomly divided into glimepiride group （60 cases） and glipizide group（66 cases）,two groups were given glimepiride and glipizide treatment,after 4 weeks of treatment,fast- ing blood glucose（FPG）,2 h postprandial blood glucose （2h PG）,fasting C peptide,2 h postprandial serum C peptide and glycosylated hemoglobin （HbAlc） content,insulin resistance （HOMA-IR） and islet beta cell function （HOMA-β） were detected, and the number of hypoglycemia reaction were recorded. Results After treatment, the FPG and HbAlc of two groups of were significantly decreased, glimepiride group decreased more obvious, fasting serum C peptide and 2 h postprandial serum C peptide of two groups all increased, serum C peptide of glimepiride group increased more,hypo- glycemia was significantly reduced,HOMA-IR decreased significantly, HOMA- β increased significantly（P〈0.05）.Con- clusion Glimepiride tablets in the treatment of type 2 diabetes has better curative effect, can reduce hypoglycemia re- action with good safety, patients＇ compliance is high, and has more dominant function in the improvement of HOMA-β.