卡前列素氨丁三醇预防高危妊娠剖宫产产后出血的临床疗效及安全性探讨

Discussion of clinical effect and safety of carboprost tromethamine for prevention of postpartum hemorrhage of high-risk pregnancy cesarean section

目的观察卡前列素氨丁三醇预防高危妊娠剖宫产产后出血的临床疗效及安全性。方法将本院83例高危妊娠产妇随机分为两组,均进行剖宫产手术分娩。对照组40例给予单纯缩宫素治疗,试验组43例给予卡前列素氨丁三醇和缩宫素治疗。观察两组产后出血量及出血率的差异,评价其不良反应的情况。结果试验组产后2、24 h出血量低于对照组,差异有统计学意义(P<0.05);试验组产后出血率为11.6%,低于对照组的32.5%,差异有统计学意义(P<0.05);试验组不良反应发生率为16.3%,稍高于对照组的12.5%,差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇预防高危妊娠剖宫产产后出血的疗效显著,能够显著降低产妇剖宫产后的出血量,降低患者产后出血的发生率,不良反应发生率较低,可促进产妇早日康复。

Objective To observe the clinical effect and safety of carboprost tromethamine for prevention of postpartum hemorrhage of high-risk pregnancy cesarean section. Methods 83 parturients with high-risk pregnancy in our hospital were randomly divided into two groups.All parturients were given cesarean sections for deliveries.40 cases of control group were given merely oxytocin for treatment while 43 eases of experiment group were given carboprost tromethamine and oxytocin for treatment.The differences of postpartum hemorrhage amount and hemorrhage rate of the two groups were observed and adverse effect conditions were evaluated. Results Hemorrhage amounts of 2 h and 24 h after deliv- ery of experiment group were less than control group,the difference was statistically significant （P〈0.05）.The hemorrhage rate after delivery in experiment group of 11.6% was obviously lower than control group （32.5%）,the difference was sta- tistically significant （P〈0.05）,the adverse effect rate in experiment group of 16.3% was slightly higher than control group （12.5%）,the difference was no statistically significant （P〉0.05）. Conclusion Carboprost tromethamine has an ob- vious clinical effect for prevention of postpartum hemorrhage of high-risk pregnancy cesarean section.It can obviously reduce hemorrhage amount of cesarean section and lower hemorrhage rate after delivery and it has small adverse effect rate.So it can promote early recovery of parturients.