垂体后叶素在腹腔镜下子宫大肌瘤剔除术的应用

APPLICATION OF HYPOPHYSIN IN LAPAROSCOPIC UTERINE MYOMECTOMY

目的：探讨垂体后叶素用于腹腔镜下子宫大肌瘤剔除术中安全性和可行性。方法选择2009年7月至2013年7月间术前诊断为子宫肌壁间肌瘤，肌瘤直径为10~13 cm的患者62例，随机分为两组，研究组术中于子宫肌瘤表面、子宫体前后壁3点注射垂体后叶素，对照组术中用缩宫素同样方法注射。结果两组手术成功率均为100%，无一例中转开腹。研究组手术时间（60.5＆#177;20.5 s）显著短于对照组（90.2＆#177;20.8 s）（P ＜0.01）；术中出血量（60＆#177;13 mL）明显少于对照组（100＆#177;20 mL）（P ＜0.01）；术后病率为0.06%（2例），低于对照组0.13%（4例）（P ＜0.01）。结论垂体后叶素3点注射法应用于腹腔镜下子宫肌壁间大肌瘤剔除术中是非常安全有效。

Objective： To investigate the safety and feasibility of the application of pituitrin in laparoscopic uterine myomectomy. Methods：62 patients diagnosed as uterine intramural myoma with the diameter from 10 to 13 cm from July 2009 to July 2013 were randomly divided into two groups, 31 cases in each group. The pituitrin was injected in the surface of hysteromyoma and the front and back of uterine body in treatment group, and oxytocin in control group with the same injection method. Results：The success rates of operation for two groups both were 100%, no cases were converted to laparotomy. The operation time of treatment group （60.5 ＆#177; 20.5min） was significantly shorter than that in control group （90.2 ＆#177; 20.8 min） （P＆lt;0.01）;it was the same with the amount of bleeding （treatment group： 60 ＆#177; 13 mL, control group： 100 ＆#177; 20 mL, P＆lt; 0.01） and postoperative morbidity rates（treatment group：0.06%, control group：0.13%, P＆lt;0.01）. Conclusion： It is safe and efficient of applicating pituitrin 3-site injection in laparoscopic uterine myomectomy.