癌症相关性疲劳流行病学及发病机制研究进展

Epidemiology and pathogenesis research progress of cancer-related fatigue

癌症相关性疲劳（CRF）是与肿瘤和（或）抗肿瘤治疗相关的疲劳，发病率高，严重影响患者生活质量。病因包括心理、生理、社会等多种影响因素，目前存在多种发病机制假说，其中炎症机制假说可能在CRF的发生、发展中发挥重要作用，多种炎症细胞因子如白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）与CRF发病显著相关。

Cancer-related fatigue （CRF） is associated with tumor and （or） anti-tumor treatment, which has a high incidence and seriously affects the life quality of patients. The etiology of CRF involves psychology, physiology and social factors. There are various hypothesis of pathogenesis and the inflammatory system may play an important role in the generation and development of CRF. A variety of inflammatory eytokines such as IL-1β, IL-6, TNF-α, CRP are significantly correlated with CRF.