胺碘酮联合美托洛尔治疗收缩性心力衰竭合并心律失常的效果观察

Effect observation of amiodarone combined with metoprolol in the treatment of systolic heart failure and arrhythmia

目的评价胺碘酮联合美托洛尔治疗收缩性心力衰竭合并心律失常的效果。方法选取2010年3月~2013年2月本院收治的34例收缩性心力衰竭合并心律失常患者,随机分为两组,各17例,对照组采用胺碘酮治疗,观察组采用胺碘酮联合美托洛尔治疗,比较两组的临床疗效、左心室射血分数、心率及不良反应发生率。结果观察组的总有效率为94.12%,对照组的总有效率为82.35%,差异有统计学意义（P〈0.05）;观察组治疗后的左心室射血分数高于对照组,心率慢于对照组,差异有统计学意义（P〈0.05）;观察组的不良反应发生率为5.88%,对照组的不良反应发生率为17.65%,差异有统计学意义（P〈0.05）。结论胺碘酮联合美托洛尔治疗收缩性心力衰竭合并心律失常效果好,安全系数高,值得临床推广应用。

Objective To evaluate the efficacy of amiodarone combined with metoprolol in the treatment of systolic heart failure and arrhythmia.Methods 34 patients with systolic heart failure and arrhythmia admitted and treated in our hospital from March 2010 to February 2013 were selected and randomly assigned to two groups,each group of 17 cases. Amiodarone was used in control group,amiodarone combined with metoprolol were used in observation group.Clinical efficacy,left ventricular ejection fraction,heart rate and incidence rate of adverse reaction was compared in two goups respectively.Results Total effective rate of observation group and control group was 94.12% and 82.35% respectively,with statistical difference（P0.05）.After treatment,left ventricular ejection fraction of observation group was higher than that of control group,heart rate of observation group was slower than that of control group,with statistical difference（P0.05）. Incidence rate of adverse reaction in observation group and control group was 5.88% and 17.65% respectively,with statistical difference（P0.05）.Conclusion Amiodarone combined with metoprolol in the treatment of systolic heart failure and arrhythmia has good efficacy and safety,which is worthy of clinical promotion and application.