慢性特发性血小板减少性紫癜患者血清sHLA-G水平测定的临床意义

Clinical significance of serum level of sHLA-G in patients with chronic idiopathic thrombocytopenic purpura

目的探讨血清可溶性人类白细胞抗原G(sHLA-G)在慢性特发性血小板减少性紫癜(CITP)中的表达及临床意义。方法采用双抗体夹心酶联免疫吸附法(ELISA)检测76例初治慢性ITP患者治疗前后血清中sHLA-G水平。结果 CITP患者治疗前sHLA-G水平明显高于对照组(P<0.05)。经治疗缓解后患者血清sHLA-G水平与治疗前相比明显下降(P<0.05)。未缓解者sHLA-G水平与初诊患者无明显差异(P>0.05)。结论 sHLA-G可能参与了CITP的发病,检测sHLA-G水平变化有助于慢性特发性血小板减少性紫癜病情判断,可作为疗效观察的新指标。

Objective To investigate clinical significance of sHLA-G in patients with chronic idiopathic thrombocytopenic purpura（CITP）. Methods Serum levels of sHLA-G in 76 patients with initial CITP were detected using enzyme-linked immunosorbent assay（ELISA）. Results The serum level of sHLA-G in initial patients with CITP was significantly higher than level of controls （P〈0.05）, The serum level of sHLA-G in those having good response after therapy was significantly lower than before treatment（P〈0.05）. There were no difference in sHLA-G between nonremission and initial patients（P〉0.05）. Conclusion Serum levels of sHLA-G in the patients with chronic idiopathic thrombocytopenic purpura is useful marker to judge state of illness, and sHLA-G may be regarded as new index of curative effect.