阿加曲班联合参芎葡萄糖治疗进展性脑梗死35例

Argatroban and ShenXiong Glucose for 35 Cases of Progressive Cerebral Infarction

目的:观察阿加曲班联合参芎葡萄糖治疗进展性脑梗死的临床疗效。方法:将70例进展性脑梗死患者随机分为治疗组和对照组各35例,治疗组给予阿加曲班和参芎葡萄糖联合常规治疗,对照组给予常规治疗,疗程为14天。观察2组治疗前、后美国国立卫生院卒中量表(NIHSS)评分和日常生活活动能力Barthel指数(Barthel)。结果:总有效率治疗组为91.43%,对照组为80.00%。2组相比差异显著(P<0.05)。NIHSS评分和Barthel指数治疗后2组均明显改善(P<0.05),但治疗组改善更明显(P<0.05)。结论:早期应用阿加曲班联合参芎葡萄糖能提高临床有效率,改善进展性脑梗死的神经功能缺损和日常生活能力。

Objective：To investigate clinical effects of argatroban and ShenXiong glucose in treating progres-sive cerebral infarction. Methods：All 70 patients were randomly allocated into the treatment group and the control group, the treatment group accepted routine treatment, argatroban and ShenXiong glucose, and the control group rou-tine treatment, one course of the treatment was 14 days. The scales of NIHSS, daily living ability and Barthel index of both groups were observed before and after treating. Results： Total effective rate of the treatment group was 91.43%, higher than 80.00% of the control group, the difference was significant （P＆lt;0.05）. NIHSS scales and Barthel indexes were improved significantly after treating （P＆lt;0.05）, and the improvement of the treatment group was more significant （P＆lt;0.05）. Conclusion：Argatroban applied in the early time and ShenXiong glucose could im-prove clinical effective rate, improve neurologic impairment and daily living ability.