初发2型糖尿病胰岛素泵早期强化对胰高血糖素样肽-1变化的价值探讨

Early insulin pump incipient type 2 diabetes improved sample of glucagon peptide-1 changeThe value to discuss

目的探讨采用胰岛素泵早期强化治疗初发2型糖尿病后患者血胰高血糖素样肽-1(GLP-1)水平的变化。方法按照随机数字表法将83例初发2型糖尿病患者分为两组,治疗组(42例)采用胰岛素泵(CSII)强化治疗,对照组(41例)常规皮下注射胰岛素。观察两组治疗后血糖、GLP-1水平、胰岛素用量、血糖达标时间及低血糖发生次数。结果治疗后的两组空腹血糖(FPG)、餐后2小时血糖(2 hPG)、GLP-1优于治疗前,差异有显著性(P<0.05);治疗组治疗后的FPG、2 hPG、GLP-1水平与治疗前的差值和对照组比较,差异有统计学意义(P<0.05),治疗组优于对照组;治疗组的胰岛素用量、血糖达标时间、低血糖次数均少于对照组,差异有统计学意义(P<0.05)。结论胰岛素泵早期强化治疗初发2型糖尿病患者,可使GLP-1水平升高,改善胰岛功能,从而有效控制血糖。

Objective To explore the early intensive insulin pump treatment of incipient type 2 diabetes mellitus patients after blood sam- ple glucagon peptide 1 （ GLP - 1 ） level changes. Methods According to random number table method, 83 patients with incipient type 2 diabetes were divided into two groups, the treatment group （42 cases） receiving intensively treated with insulin pump （CSII） and control group （41 cases） receiving conventional subcutaneous insulin injections. Results After treatment, FPG, 2 HPG, GLP - 1 of two groups are better than those of be- fore the treatment. The difference was statistically significant （ P 〈 O. 05 ）. FPG, 2 HPG, GLP - 1 level of treatment group after treatment com- pared with before treatment and the control group. The difference was statistically significant （ P 〈 O. 05 ）. Treatment group was superior to control group. The dosage of insulin, blood glucose control, hypoglycemia times of treatment groupare less than those of the control group. The difference were statistically significant （ P 〈 0.05 ）. Conclusion Early intensive insulin pump treatment early in patients with type 2 diabetes can make the GLP - 1 levels increasing, improve the function of islet, effectively control blood sugar.